The LPA3 Receptor: Regulation and Activation of Signaling Pathways

The lysophosphatidic acid 3 receptor (LPA3) participates in different physiological actions and in the pathogenesis of many diseases through the activation of different signal pathways. Knowledge of the regulation of the function of the LPA3 receptor is a crucial element for defining its roles in he...

Full description

Saved in:
Bibliographic Details
Published in:International journal of molecular sciences 2021-07, Vol.22 (13), p.6704
Main Authors: Solís, Karina Helivier, Romero-Ávila, M. Teresa, Guzmán-Silva, Alejandro, García-Sáinz, J. Adolfo
Format: Article
Language:English
Subjects:
Alzheimer's disease
Antioxidants
Apoptosis
Cancer
Cardiomyocytes
Desensitization
Enzymes
Fatty acids
Glycerol
GRK
Heart attacks
Internalization
Kinases
Lipids
Localization
LPA3
Lysophosphatidic acid
lysophosphatidic acid 3 receptor
Nervous system
PKC
Proteins
receptor phosphorylation
Review
Signal transduction
Therapeutic applications
Transcription factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The lysophosphatidic acid 3 receptor (LPA3) participates in different physiological actions and in the pathogenesis of many diseases through the activation of different signal pathways. Knowledge of the regulation of the function of the LPA3 receptor is a crucial element for defining its roles in health and disease. This review describes what is known about the signaling pathways activated in terms of its various actions. Next, we review knowledge on the structure of the LPA3 receptor, the domains found, and the roles that the latter might play in ligand recognition, signaling, and cellular localization. Currently, there is some information on the action of LPA3 in different cells and whole organisms, but very little is known about the regulation of its function. Areas in which there is a gap in our knowledge are indicated in order to further stimulate experimental work on this receptor and on other members of the LPA receptor family. We are convinced that knowledge on how this receptor is activated, the signaling pathways employed and how the receptor internalization and desensitization are controlled will help design new therapeutic interventions for treating diseases in which the LPA3 receptor is implicated.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms22136704