The radiologist’s role in detecting systemic anticancer therapy-related interstitial lung disease: an educational review

Systemic anticancer therapies (SACTs) are the leading cause of drug-induced interstitial lung disease (ILD). As more novel SACTs become approved, the incidence of this potentially life-threatening adverse event (AE) may increase. Early detection of SACT-related ILD allows for prompt implementation o...

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Bibliographic Details
Published in:Insights into imaging 2024-08, Vol.15 (1), p.191-14, Article 191
Main Authors: Dinkel, Julien, Kneidinger, Nikolaus, Tarantino, Paolo
Format: Article
Language:English
Subjects:
Asymptomatic
Cancer
Computed tomography
Diagnosis
Diagnostic Radiology
Drug-related side effects and adverse reactions
Educational Review
Health services
High resolution
Imaging
Internal Medicine
Interventional Radiology
Lung diseases
Lung diseases, Interstitial
Medicine
Medicine & Public Health
Multidisciplinary teams
Neoplasms
Neuroradiology
Pneumonia
Prognosis
Radiology
Signs and symptoms
Tomography
Tomography (x-ray computed)
Ultrasound
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Summary:Systemic anticancer therapies (SACTs) are the leading cause of drug-induced interstitial lung disease (ILD). As more novel SACTs become approved, the incidence of this potentially life-threatening adverse event (AE) may increase. Early detection of SACT-related ILD allows for prompt implementation of drug-specific management recommendations, improving the likelihood of AE resolution and, in some instances, widening the patient’s eligibility for future cancer treatment options. ILD requires a diagnosis of exclusion through collaboration with the patient’s multidisciplinary team to rule out other possible etiologies of new or worsening respiratory signs and symptoms. At Grade 1, ILD is asymptomatic, and thus the radiologist is key to detecting the AE prior to the disease severity worsening. Planned computed tomography scans should be reviewed for the presence of ILD in addition to being assessed for tumor response to treatment, and when ILD is suspected, a high-resolution computed tomography (HRCT) scan should be requested immediately. An HRCT scan, with
ISSN:1869-4101
1869-4101
DOI:10.1186/s13244-024-01771-z