Epithelial-Mesenchymal Transition in Acute Leukemias

Epithelial-mesenchymal transition (EMT) is a metabolic process that confers phenotypic flexibility to cells and the ability to adapt to new functions. This transition is critical during embryogenesis and is required for the differentiation of many tissues and organs. EMT can also be induced in advan...

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Bibliographic Details
Published in:International journal of molecular sciences 2024-02, Vol.25 (4), p.2173
Main Authors: Varisli, Lokman, Vlahopoulos, Spiros
Format: Article
Language:English
Subjects:
Cancer
cell adhesion
Cell Differentiation
Chemotherapy
Cytokines
EMT
Epithelial-Mesenchymal Transition
Gene expression
Growth factors
Humans
Hypoxia
Immune system
Kinases
Leukemia
Leukocytes
Mutation
neoplasia
Neoplasms - metabolism
signaling
Stem cells
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Summary:Epithelial-mesenchymal transition (EMT) is a metabolic process that confers phenotypic flexibility to cells and the ability to adapt to new functions. This transition is critical during embryogenesis and is required for the differentiation of many tissues and organs. EMT can also be induced in advanced-stage cancers, leading to further malignant behavior and chemotherapy resistance, resulting in an unfavorable prognosis for patients. Although EMT was long considered and studied only in solid tumors, it has been shown to be involved in the pathogenesis of hematological malignancies, including acute leukemias. Indeed, there is increasing evidence that EMT promotes the progression of acute leukemias, leading to the emergence of a more aggressive phenotype of the disease, and also causes chemotherapy resistance. The current literature suggests that the levels and activities of EMT inducers and markers can be used to predict prognosis, and that targeting EMT in addition to conventional therapies may increase treatment success in acute leukemias.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms25042173