Clusters of Drug-Resistant Mycobacterium tuberculosis Detected by Whole-Genome Sequence Analysis of Nationwide Sample, Thailand, 2014-2017

Multidrug-resistant tuberculosis (MDR TB), pre-extensively drug-resistant tuberculosis (pre-XDR TB), and extensively drug-resistant tuberculosis (XDR TB) complicate disease control. We analyzed whole-genome sequence data for 579 phenotypically drug-resistant M. tuberculosis isolates (28% of availabl...

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Bibliographic Details
Published in:Emerging infectious diseases 2021-03, Vol.27 (3), p.813-822
Main Authors: Nonghanphithak, Ditthawat, Chaiprasert, Angkana, Smithtikarn, Saijai, Kamolwat, Phalin, Pungrassami, Petchawan, Chongsuvivatwong, Virasakdi, Mahasirimongkol, Surakameth, Reechaipichitkul, Wipa, Leepiyasakulchai, Chaniya, Phelan, Jody E, Blair, David, Clark, Taane G, Faksri, Kiatichai
Format: Article
Language:English
Subjects:
Antimicrobial agents
Antitubercular Agents - therapeutic use
Cluster analysis
Clustering
Clusters of Drug-Resistant
Detected by Whole-Genome Sequence Analysis of Nationwide Sample, Thailand, 2014–2017
Disease control
Distribution
DNA sequencing
Drug resistance
Drug resistance in microorganisms
Drug Resistance, Multiple, Bacterial
Genetic aspects
Genomes
Geography
Humans
Laboratories
Methods
Microbial Sensitivity Tests
Multidrug resistant organisms
multidrug-resistant TB
Mutation
Mycobacterium tuberculosis
Nucleotide sequencing
Pharmaceutical Preparations
Phylogenetics
Population
Public health
Risk factors
Sequence Analysis
Thailand
transmission
Tuberculosis
Tuberculosis, Multidrug-Resistant - drug therapy
whole-genome sequencing
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Summary:Multidrug-resistant tuberculosis (MDR TB), pre-extensively drug-resistant tuberculosis (pre-XDR TB), and extensively drug-resistant tuberculosis (XDR TB) complicate disease control. We analyzed whole-genome sequence data for 579 phenotypically drug-resistant M. tuberculosis isolates (28% of available MDR/pre-XDR and all culturable XDR TB isolates collected in Thailand during 2014-2017). Most isolates were from lineage 2 (n = 482; 83.2%). Cluster analysis revealed that 281/579 isolates (48.5%) formed 89 clusters, including 205 MDR TB, 46 pre-XDR TB, 19 XDR TB, and 11 poly-drug-resistant TB isolates based on genotypic drug resistance. Members of most clusters had the same subset of drug resistance-associated mutations, supporting potential primary resistance in MDR TB (n = 176/205; 85.9%), pre-XDR TB (n = 29/46; 63.0%), and XDR TB (n = 14/19; 73.7%). Thirteen major clades were significantly associated with geography (p
ISSN:1080-6040
1080-6059
DOI:10.3201/eid2703.204364