Overview of host miRNA properties and their association with epigenetics, long non-coding RNAs, and Xeno-infectious factors

MicroRNA-derived structures play impressive roles in various biological processes. So dysregulation of miRNAs can lead to different human diseases. Recent studies have extended our comprehension of the control of miRNA function and features. Here, we overview some remarkable miRNA properties that ha...

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Bibliographic Details
Published in:Cell & bioscience 2021-02, Vol.11 (1), p.43-43, Article 43
Main Authors: Heydarzadeh, Samaneh, Ranjbar, Maryam, Karimi, Farokh, Seif, Farhad, Alivand, Mohammad Reza
Format: Article
Language:English
Subjects:
Adenosine
Alzheimer's disease
Arm selection
Biomarkers
Cancer
Cytoplasm
Deoxyribonucleic acid
DNA
DNA methylation
Editing
Enzymes
Epigenetic inheritance
Epigenetics
Gene expression
Genomes
IsomiR
LncRNA
Medical research
Medicine, Experimental
Methylation
MicroRNA
MicroRNAs
miRNA
Non-coding RNA
Parasites
Precision medicine
Proteins
Review
Seeds
Signal transduction
Therapeutic applications
Xeno-infection
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Summary:MicroRNA-derived structures play impressive roles in various biological processes. So dysregulation of miRNAs can lead to different human diseases. Recent studies have extended our comprehension of the control of miRNA function and features. Here, we overview some remarkable miRNA properties that have potential implications for the miRNA functions, including different variants of a miRNA called isomiRs, miRNA arm selection/arm switching, and the effect of these factors on miRNA target selection. Besides, we review some aspects of miRNA interactions such as the interaction between epigenetics and miRNA (different miRNAs and their related processing enzymes are epigenetically regulated by multiple DNA methylation enzymes. moreover, DNA methylation could be controlled by diverse mechanisms related to miRNAs), direct and indirect crosstalk between miRNA and lnc (Long Non-Coding) RNAs as a further approach to conduct intercellular regulation called "competing endogenous RNA" (ceRNA) that is involved in the pathogenesis of different diseases, and the interaction of miRNA activities and some Xeno-infectious (virus/bacteria/parasite) factors, which result in modulation of the pathogenesis of infections. This review provides some related studies to a better understanding of miRNA involvement mechanisms and overcoming the complexity of related diseases that may be applicable and useful to prognostic, diagnostic, therapeutic purposes and personalized medicine in the future.
ISSN:2045-3701
2045-3701
DOI:10.1186/s13578-021-00552-1