Anti- Candida Potential of Sclareol in Inhibiting Growth, Biofilm Formation, and Yeast-Hyphal Transition

Even though commonly colonizes on most mucosal surfaces including the vaginal and gastrointestinal tract, it can cause candidiasis as an opportunistic infectious fungus. The emergence of resistant strains and the toxicity of anti-fungal agents have encouraged the development of new classes of potent...

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Bibliographic Details
Published in:Journal of fungi (Basel) 2023-01, Vol.9 (1), p.98
Main Authors: Kim, Chaerim, Kim, Jae-Goo, Kim, Ki-Young
Format: Article
Language:English
Subjects:
anti-fungal
Apoptosis
Biofilms
Candida
Candida albicans
Candidiasis
Cell cycle
Cell death
Cell membranes
Fungi
Gastrointestinal tract
Membrane permeability
Membrane potential
Minimum inhibitory concentration
Mitochondria
Nosocomial infections
Propidium iodide
sclareol
Toxicity
Virulence
Virulence factors
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Summary:Even though commonly colonizes on most mucosal surfaces including the vaginal and gastrointestinal tract, it can cause candidiasis as an opportunistic infectious fungus. The emergence of resistant strains and the toxicity of anti-fungal agents have encouraged the development of new classes of potential anti-fungal agents. Sclareol, a labdane-type diterpene, showed anti- activity with a minimum inhibitory concentration of 50 μg/mL in 24 h based on a microdilution anti-fungal susceptibility test. Cell membrane permeability with propidium iodide staining and mitochondrial membrane potential with JC-1 staining were increased in by treatment of sclareol. Sclareol also suppressed the hyphal formation of in both liquid and solid media, and reduced biofilm formation. Taken together, sclareol induces an apoptosis-like cell death against spp. and suppressed biofilm and hyphal formation in . Sclareol is of high interest as a novel anti-fungal agent and anti-virulence factor.
ISSN:2309-608X
2309-608X
DOI:10.3390/jof9010098