Endoplasmic Reticulum Stress-Related Ten-Biomarker Risk Classifier for Survival Evaluation in Epithelial Ovarian Cancer and TRPM2: A Potential Therapeutic Target of Ovarian Cancer

Epithelial ovarian cancer (EOC) is the most lethal gynecological malignant tumor. Endoplasmic reticulum (ER) stress plays an important role in the malignant behaviors of several tumors. In this study, we established a risk classifier based on 10 differentially expressed genes related to ER stress to...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-09, Vol.24 (18), p.14010
Main Authors: Zhang, Minghai, Wang, Yingjie, Xu, Shilin, Huang, Shan, Wu, Meixuan, Chen, Guangquan, Wang, Yu
Format: Article
Language:English
Subjects:
Apoptosis
Biomarkers
Cell cycle
Clinical outcomes
endoplasmic reticulum stress
epithelial ovarian cancer
Genes
Medical prognosis
Ovarian cancer
Patients
Proteins
risk classifier
TRPM2
Tumors
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Summary:Epithelial ovarian cancer (EOC) is the most lethal gynecological malignant tumor. Endoplasmic reticulum (ER) stress plays an important role in the malignant behaviors of several tumors. In this study, we established a risk classifier based on 10 differentially expressed genes related to ER stress to evaluate the prognosis of patients and help to develop novel medical decision-making for EOC cases. A total of 378 EOC cases with transcriptome data from the TCGA-OV public dataset were included. Cox regression analysis was used to establish a risk classifier based on 10 ER stress-related genes (ERGs). Then, through a variety of statistical methods, including survival analysis and receiver operating characteristic (ROC) methods, the prediction ability of the proposed classifier was tested and verified. Similar results were confirmed in the GEO cohort. In the immunoassay, the different subgroups showed different penetration levels of immune cells. Finally, we conducted loss-of-function experiments to silence TRPM2 in the human EOC cell line. We created a 10-ERG risk classifier that displays a powerful capability of survival evaluation for EOC cases, and TRPM2 could be a potential therapeutic target of ovarian cancer cells.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms241814010