Early left ventricular microvascular dysfunction in diabetic pigs: a longitudinal quantitative myocardial perfusion CMR study

• Published in: Cardiovascular diabetology 2024-01, Vol.23 (1), p.9-9, Article 9
• Main Authors: Jiang, Li, Yan, Wei-Feng, Zhang, Lu, Xu, Hua-Yan, Guo, Ying-Kun, Li, Zhen-Lin, Liu, Ke-Ling, Zeng, Ling-Ming, Li, Yuan, Yang, Zhi-Gang
• Format: Article
• Language: English
• Subjects: Animals; Blood flow; Blood Glucose; Cardiomyopathy; Cardiovascular disease; Diabetes; Diabetes mellitus; Diabetes Mellitus, Experimental; Heart; Hogs; Longitudinal studies; Magnetic resonance imaging; Microvascular dysfunction; Microvasculature; Myocardial microvascular reserve function; Perfusion; Quantitative myocardial perfusion; Software; Streptozocin; Structure-function relationships; Swine; Ventricle; Ventricular Dysfunction, Left - diagnostic imaging; Ventricular Dysfunction, Left - etiology
• ISSN: 1475-2840; 1475-2840
• DOI: 10.1186/s12933-023-02106-w

Microvascular pathology is one of the main characteristics of diabetic cardiomyopathy; however, the early longitudinal course of diabetic microvascular dysfunction remains uncertain. This study aimed to investigate the early dynamic changes in left ventricular (LV) microvascular function in diabetic pig model using the cardiac magnetic resonance (CMR)-derived quantitative perfusion technique. Twelve pigs with streptozotocin-induced diabetes mellitus (DM) were included in this study, and longitudinal CMR scanning was performed before and 2, 6, 10, and 16 months after diabetic modeling. CMR-derived semiquantitative parameters (upslope, maximal signal intensity, perfusion index, and myocardial perfusion reserve index [MPRI]) and fully quantitative perfusion parameters (myocardial blood flow [MBF] and myocardial perfusion reserve [MPR]) were analyzed to evaluate longitudinal changes in LV myocardial microvascular function. Pearson correlation was used to analyze the relationship between LV structure and function and myocardial perfusion function. With the progression of DM duration, the upslope at rest showed a gradually increasing trend (P = 0.029); however, the upslope at stress and MBF did not change significantly (P > 0.05). Regarding perfusion reserve function, both MPRI and MPR showed a decreasing trend with the progression of disease duration (MPRI, P = 0.001; MPR, P = 0.042), with high consistency (r = 0.551, P