Dinuclear Molybdenum(VI) Complexes Based on Flexible Succinyl and Adipoyl Dihydrazones

A series of molybdenum(VI) complexes with aryl-functionalized alkyl dihydrazones was prepared by the reaction of [MoO2(acac)2] and the appropriate dihydrazone in methanol. Their solid-state structures were elucidated via single-crystal X-ray diffraction (SC-XRD) and Fourier-transform infra-red (FTIR...

Full description

Saved in:
Bibliographic Details
Published in:Crystals (Basel) 2024-01, Vol.14 (2), p.135
Main Authors: Topić, Edi, Damjanović, Vladimir, Pičuljan, Katarina, Rubčić, Mirta
Format: Article
Language:English
Subjects:
Chemical properties
Chemical synthesis
Coliforms
cytotoxic and antibacterial activity
Cytotoxicity
E coli
Fourier transforms
hydrazones
Ligands
Methods
Mo(VI) complexes
Molybdenum
Molybdenum compounds
Nitrogen
NMR
NMR spectroscopy
Nuclear magnetic resonance
Radiation
Single crystals
Software
Stability analysis
structural analysis
Thermal stability
Thermogravimetric analysis
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A series of molybdenum(VI) complexes with aryl-functionalized alkyl dihydrazones was prepared by the reaction of [MoO2(acac)2] and the appropriate dihydrazone in methanol. Their solid-state structures were elucidated via single-crystal X-ray diffraction (SC-XRD) and Fourier-transform infra-red (FTIR) spectroscopy, while the thermal stability of compounds was inspected by combined thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) experiments. The behaviour of complexes in DMSO-d6 solution was explored by nuclear magnetic resonance (NMR). The relevant data show that all complexes are dinuclear, with dihydrazones acting as ditopic hexadentate ligands. The in vitro cytotoxic activity of the prepared molybdenum(VI) complexes was evaluated on THP-1 and HepG2 cell lines, while their antibacterial activity was tested against Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, and Moraxella catarrhalis bacteria. The majority of compounds proved to be non-cytotoxic, while some exhibited superior antibacterial activity in comparison to dihydrazone ligands.
ISSN:2073-4352
2073-4352
DOI:10.3390/cryst14020135