Rapid detection of bacille Calmette-Guérin-associated mycotic aortic aneurysm using novel cell-free DNA assay

AbstractIntravesical instillation of bacille Calmette-Guérin (BCG), an attenuated strain of Mycobacterium bovis, is an adjuvant immunotherapy for bladder carcinoma. Typical complications include fever, malaise, and dysuria. However, more severe complications have been reported, including granulomato...

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Bibliographic Details
Published in:Journal of vascular surgery cases and innovative techniques 2019-06, Vol.5 (2), p.143-148
Main Authors: Vudatha, Vignesh, BS, Ranson, Mark, MD, Blair, Lily, PhD, Ahmed, Asim A., MD
Format: Article
Language:English
Subjects:
BCG
Cell-free DNA
Mycobacterium
Mycotic aortic aneurysm
Next-generation sequencing
Surgery
Vascular infection
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Summary:AbstractIntravesical instillation of bacille Calmette-Guérin (BCG), an attenuated strain of Mycobacterium bovis, is an adjuvant immunotherapy for bladder carcinoma. Typical complications include fever, malaise, and dysuria. However, more severe complications have been reported, including granulomatous pneumonitis, BCG sepsis, and vascular infections. We present a case of an infrarenal abdominal aortic aneurysm complicated by iliopsoas abscess 2 years after BCG treatment and discuss a novel diagnostic tool for mycobacterial strain identification.
ISSN:2468-4287
2468-4287
DOI:10.1016/j.jvscit.2018.11.006