Salivary cytokine profile in patients with ischemic stroke

Inflammation plays a crucial role in stroke pathogenesis. Thus, it is not surprising that cytokines, chemokines, and growth factors have been advocated in stroke diagnostics. Our study is the first to evaluate the salivary cytokine profile in patients with ischemic stroke. Twenty-five patients with...

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Bibliographic Details
Published in:Scientific reports 2021-08, Vol.11 (1), p.17185-17185, Article 17185
Main Authors: Maciejczyk, Mateusz, Mil, Kacper Maksymilian, Gerreth, Piotr, Hojan, Katarzyna, Zalewska, Anna, Gerreth, Karolina
Format: Article
Language:English
Subjects:
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Chemokines
Cognitive ability
Cytokines
Growth factors
Humanities and Social Sciences
Hygiene
Interleukin 10
Interleukin 6
Ischemia
multidisciplinary
Oral hygiene
Saliva
Science
Science (multidisciplinary)
Stroke
Tumor necrosis factor-TNF
Tumor necrosis factor-α
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Summary:Inflammation plays a crucial role in stroke pathogenesis. Thus, it is not surprising that cytokines, chemokines, and growth factors have been advocated in stroke diagnostics. Our study is the first to evaluate the salivary cytokine profile in patients with ischemic stroke. Twenty-five patients with subacute ischemic stroke and an age-, sex-, and oral hygiene status-matched control group were enrolled in the study. The number of patients was set a priori based on our previous experiment (α = 0.05, test power = 0.9). Salivary concentrations of tumor necrosis factor α (TNF-α), interleukin 6 (IL-6), and interleukin 10 (IL-10) were assessed using an ELISA method. We showed that salivary TNF-α and IL-6 were significantly higher, whereas IL-10 content was statistically lower in both non-stimulated (NWS) and stimulated (SWS) whole saliva of ischemic stroke patients. However, evaluation of cytokines in NWS rather than in SWS may be of greater diagnostic value. Of particular note is salivary TNF-α, which may indicate cognitive/physical impairment in post-stroke individuals. This parameter distinguishes stroke patients from healthy controls and correlates with cognitive decline and severity of functional impairment. It also differentiates (with high sensitivity and specificity) stroke patients with normal cognition from mild to moderate cognitive impairment. Saliva may be an alternative to blood for assessing cytokines in stroke patients, although further studies on a larger patient population are needed.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-96739-0