Adropin Predicts Asymptomatic Heart Failure in Patients with Type 2 Diabetes Mellitus Independent of the Levels of Natriuretic Peptides

In patients with type 2 diabetes mellitus (T2DM), asymptomatic adverse cardiac remodeling plays a pivotal role in the development of heart failure (HF). Patients with T2DM often have low or near-normal levels of natriuretic peptides, including N-terminal brain natriuretic peptide (NT-proBNP), which...

Full description

Saved in:
Bibliographic Details
Published in:Diagnostics (Basel) 2024-08, Vol.14 (16), p.1728
Main Authors: Berezina, Tetiana A, Berezin, Oleksandr O, Hoppe, Uta C, Lichtenauer, Michael, Berezin, Alexander E
Format: Article
Language:English
Subjects:
adropin
adverse cardiac remodeling
Biomarkers
circulating biomarkers
Complications and side effects
Health aspects
Heart failure
heart failure with preserved ejection fraction
Insulin resistance
Kidney diseases
Kinases
Natriuretic peptides
Risk factors
Type 2 diabetes
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In patients with type 2 diabetes mellitus (T2DM), asymptomatic adverse cardiac remodeling plays a pivotal role in the development of heart failure (HF). Patients with T2DM often have low or near-normal levels of natriuretic peptides, including N-terminal brain natriuretic peptide (NT-proBNP), which have been inconclusive in predicting the transition from asymptomatic adverse cardiac remodeling to HF with preserved ejection fraction (HFpEF). The aim of this study was to elucidate the predictive ability of adropin for HFpEF depending on the circulating levels of NT-proBNP. We prospectively enrolled 561 T2DM patients (glycated hemoglobin < 6.9%) with echocardiographic evidence of structural cardiac abnormalities and left ventricular ejection fractions >50%. All patients underwent B-mode transthoracic echocardiographic and Doppler examinations. Circulating biomarkers, i.e., NT-proBNP and adropin, were assessed at baseline. All individuals were divided into two groups according to the presence of low levels (
ISSN:2075-4418
2075-4418
DOI:10.3390/diagnostics14161728