Minnesota wild hemp: a crucial botanical source in early cannabinoid discovery

Renewed and sustained Cannabis chemistry exploration was initiated by Roger Adams at the University of Illinois Chemistry Department with cooperation from the Treasury Department Narcotics Laboratory in the early 1940's. This partnership and time investment by both parties made practical sense....

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Bibliographic Details
Published in:Journal of cannabis research 2020-09, Vol.2 (1), p.25-25, Article 25
Main Author: Filer, Crist N
Format: Article
Language:English
Subjects:
Cannabidiol
Cannabinoid
Chemistry
Creativity
Ethanol
Federal Bureau of Narcotics
Hemp
Laboratories
Marijuana
Minnesota wild hemp
Narcotics
Natural products
Review
Roger Adams
Success
University of Illinois
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Summary:Renewed and sustained Cannabis chemistry exploration was initiated by Roger Adams at the University of Illinois Chemistry Department with cooperation from the Treasury Department Narcotics Laboratory in the early 1940's. This partnership and time investment by both parties made practical sense. Adams was able to explore natural products chemistry and the Narcotics Laboratory began to clarify the chemistry mysteries of Cannabis. Minnesota wild hemp, often viewed as just a roadside weed, was employed as the critical botanical source. Based on its widespread cultivation during World War II, this was also a very pragmatic decision. Although the unique Illinois - Washington D. C. collaboration lasted only a few short years (1939-1942), the stunning results included the isolation and extensive characterization of cannabidiol, the structure elucidation and total synthesis of cannabinol as well as the identification of the tetrahydrocannabinol structure as an intoxicating pharmacophore. Furthermore, this research well prepared many junior chemists for prolific careers in both academia as well as industry, inspired the discoveries of later Cannabis investigators and also provided a successful model of a productive academic-government partnership.
ISSN:2522-5782
2522-5782
DOI:10.1186/s42238-020-00031-3