KLB and NOX4 expression levels as potential blood-based transcriptional biomarkers of physical activity in children

Insufficient physical activity (PA) in children is considered one of the major contributors to obesity and cardiometabolic complications later in life. Although regular exercise may contribute to disease prevention and health promotion, reliable early biomarkers are required to objectively discern p...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2023-04, Vol.13 (1), p.5563-5563, Article 5563
Main Authors: Galmés, Sebastià, Rupérez, Azahara I., Sánchez, Juana, Moreno, Luis A., Foraita, Ronja, Hebestreit, Antje, Molnár, Dénes, Palou, Andreu, Picó, Catalina
Format: Article
Language:English
Subjects:
631/208/199
692/53
Biomarkers
Blood cells
Cardiovascular Diseases - prevention & control
Child
Children
Exercise
Exercise - physiology
Gene regulation
Genomes
Health promotion
Humanities and Social Sciences
Humans
Klotho Proteins
Morphogenesis
multidisciplinary
NADPH Oxidase 4
NOX4 protein
Obesity
Peripheral blood
Physical activity
Physical fitness
Physical training
Science
Science (multidisciplinary)
Sedentary Behavior
Wound healing
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Insufficient physical activity (PA) in children is considered one of the major contributors to obesity and cardiometabolic complications later in life. Although regular exercise may contribute to disease prevention and health promotion, reliable early biomarkers are required to objectively discern people performing low PA from those who exercise enough. Here, we aimed to identify potential transcript-based biomarkers through the analysis of a whole-genome microarray in peripheral blood cells (PBC) from physically less active (n = 10) comparing with more active (n = 10) children. A set of genes differentially expressed (p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-31537-4