Multimodal imaging of the aging brain: Baseline findings of the LoCARPoN study

We quantified and investigated multimodal brain MRI measures in the LoCARPoN Study due to lack of normative data among Indians. A total of 401 participants (aged 50–88 years) without stroke or dementia completed MRI investigation. We assessed 31 brain measures in total using four brain MRI modalitie...

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Bibliographic Details
Published in:Aging brain 2023-01, Vol.3, p.100075-100075, Article 100075
Main Authors: Nair, Pallavi, Prasad, Kameshwar, Balasundaram, Parthiban, Vibha, Deepti, Nand Dwivedi, Sada, Gaikwad, Shailesh B., Srivastava, Achal K., Verma, Vivek
Format: Article
Language:English
Subjects:
Aging
Multimodal MRI
Neuroimaging
Population-based study
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Summary:We quantified and investigated multimodal brain MRI measures in the LoCARPoN Study due to lack of normative data among Indians. A total of 401 participants (aged 50–88 years) without stroke or dementia completed MRI investigation. We assessed 31 brain measures in total using four brain MRI modalities, including macrostructural (global & lobar volumes, white matter hyperintensities [WMHs]), microstructural (global and tract-specific white matter fractional anisotropy [WM-FA] and mean diffusivity [MD]) and perfusion measures (global and lobar cerebral blood flow [CBF]). The absolute brain volumes of males were significantly larger than those of females, but such differences were relatively small (
ISSN:2589-9589
2589-9589
DOI:10.1016/j.nbas.2023.100075