Loading…

Unmasking a two-faced protein

Single-molecule fluorescence spectroscopy and molecular dynamics simulations illuminate the structure and dynamics of PSD-95, a protein involved in neural plasticity.

Saved in:
Bibliographic Details
Published in:eLife 2022-10, Vol.11
Main Authors: Maslov, Ivan, Hendrix, Jelle
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites cdi_FETCH-LOGICAL-c511t-fae8a5be53c1d7a9e67f067e855243b4621d8fcd22ac8867aa8091dd03fcacc3
container_end_page
container_issue
container_start_page
container_title eLife
container_volume 11
creator Maslov, Ivan
Hendrix, Jelle
description Single-molecule fluorescence spectroscopy and molecular dynamics simulations illuminate the structure and dynamics of PSD-95, a protein involved in neural plasticity.
doi_str_mv 10.7554/eLife.83482
format article
fullrecord <record><control><sourceid>gale_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_505ca1b844ee40039b7f30aa418fadc4</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A723233258</galeid><doaj_id>oai_doaj_org_article_505ca1b844ee40039b7f30aa418fadc4</doaj_id><sourcerecordid>A723233258</sourcerecordid><originalsourceid>FETCH-LOGICAL-c511t-fae8a5be53c1d7a9e67f067e855243b4621d8fcd22ac8867aa8091dd03fcacc3</originalsourceid><addsrcrecordid>eNptkt-LEzEQgBdR8DjvyWeh4Isirfm5SV-E4_C0UBD0BN_CbDJZU3c3Ndk9vf_etD3kVkweMky--UKGqarnlKyUlOItboPHleZCs0fVGSOSLIkW3x4_iJ9WFznvSFlKaE3XZ9WLr0MP-UcY2gUsxl9x6cGiW-xTHDEMz6onHrqMF_fneXVz_f7m6uNy--nD5upyu7SS0rHUoAbZoOSWOgVrrJUntUItJRO8ETWjTnvrGAOrda0ANFlT5wj3Fqzl59XmpHURdmafQg_pzkQI5piIqTWQxmA7NJJIC7TRQiAKQvi6UZ4TAEG1B2dFcb07ufZT06OzOIwJupl0fjOE76aNt2YtNZWsLoJX94IUf06YR9OHbLHrYMA4ZcMUqwVRnBzQl_-guziloXSqUJxIruVDqoXygTD4WN61B6m5VIwzzpnUhVr9hyrbYR9sHNCHkp8VvJ4VFGbE32MLU85m8-XznH1zYm2KOSf0f_tBiTkMjzkOjzkOD_8DKvK0Qg</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2730538506</pqid></control><display><type>article</type><title>Unmasking a two-faced protein</title><source>Publicly Available Content Database</source><source>PubMed Central</source><creator>Maslov, Ivan ; Hendrix, Jelle</creator><creatorcontrib>Maslov, Ivan ; Hendrix, Jelle</creatorcontrib><description>Single-molecule fluorescence spectroscopy and molecular dynamics simulations illuminate the structure and dynamics of PSD-95, a protein involved in neural plasticity.</description><identifier>ISSN: 2050-084X</identifier><identifier>EISSN: 2050-084X</identifier><identifier>DOI: 10.7554/eLife.83482</identifier><language>eng</language><publisher>Cambridge: eLife Science Publications, Ltd</publisher><subject>Chemical bonds ; Fluorescence spectroscopy ; Insight ; Ligands ; Microscopy ; Molecular dynamics ; Neurons ; Neuroplasticity ; Neuroscience ; Neurotransmission ; postsynaptic density ; Postsynaptic density proteins ; protein dynamics ; Proteins ; Signal transduction ; Simulation ; Simulation methods ; single molecule fluorescence ; single-molecule FRET ; Structural Biology and Molecular Biophysics</subject><ispartof>eLife, 2022-10, Vol.11</ispartof><rights>COPYRIGHT 2022 eLife Science Publications, Ltd.</rights><rights>2022, Maslov and Hendrix. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022, Maslov and Hendrix 2022 Maslov and Hendrix</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c511t-fae8a5be53c1d7a9e67f067e855243b4621d8fcd22ac8867aa8091dd03fcacc3</cites><orcidid>0000-0001-5731-1297 ; 0000-0003-3371-4416</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2730538506/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2730538506?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids></links><search><creatorcontrib>Maslov, Ivan</creatorcontrib><creatorcontrib>Hendrix, Jelle</creatorcontrib><title>Unmasking a two-faced protein</title><title>eLife</title><description>Single-molecule fluorescence spectroscopy and molecular dynamics simulations illuminate the structure and dynamics of PSD-95, a protein involved in neural plasticity.</description><subject>Chemical bonds</subject><subject>Fluorescence spectroscopy</subject><subject>Insight</subject><subject>Ligands</subject><subject>Microscopy</subject><subject>Molecular dynamics</subject><subject>Neurons</subject><subject>Neuroplasticity</subject><subject>Neuroscience</subject><subject>Neurotransmission</subject><subject>postsynaptic density</subject><subject>Postsynaptic density proteins</subject><subject>protein dynamics</subject><subject>Proteins</subject><subject>Signal transduction</subject><subject>Simulation</subject><subject>Simulation methods</subject><subject>single molecule fluorescence</subject><subject>single-molecule FRET</subject><subject>Structural Biology and Molecular Biophysics</subject><issn>2050-084X</issn><issn>2050-084X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptkt-LEzEQgBdR8DjvyWeh4Isirfm5SV-E4_C0UBD0BN_CbDJZU3c3Ndk9vf_etD3kVkweMky--UKGqarnlKyUlOItboPHleZCs0fVGSOSLIkW3x4_iJ9WFznvSFlKaE3XZ9WLr0MP-UcY2gUsxl9x6cGiW-xTHDEMz6onHrqMF_fneXVz_f7m6uNy--nD5upyu7SS0rHUoAbZoOSWOgVrrJUntUItJRO8ETWjTnvrGAOrda0ANFlT5wj3Fqzl59XmpHURdmafQg_pzkQI5piIqTWQxmA7NJJIC7TRQiAKQvi6UZ4TAEG1B2dFcb07ufZT06OzOIwJupl0fjOE76aNt2YtNZWsLoJX94IUf06YR9OHbLHrYMA4ZcMUqwVRnBzQl_-guziloXSqUJxIruVDqoXygTD4WN61B6m5VIwzzpnUhVr9hyrbYR9sHNCHkp8VvJ4VFGbE32MLU85m8-XznH1zYm2KOSf0f_tBiTkMjzkOjzkOD_8DKvK0Qg</recordid><startdate>20221019</startdate><enddate>20221019</enddate><creator>Maslov, Ivan</creator><creator>Hendrix, Jelle</creator><general>eLife Science Publications, Ltd</general><general>eLife Sciences Publications Ltd</general><general>eLife Sciences Publications, Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-5731-1297</orcidid><orcidid>https://orcid.org/0000-0003-3371-4416</orcidid></search><sort><creationdate>20221019</creationdate><title>Unmasking a two-faced protein</title><author>Maslov, Ivan ; Hendrix, Jelle</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c511t-fae8a5be53c1d7a9e67f067e855243b4621d8fcd22ac8867aa8091dd03fcacc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Chemical bonds</topic><topic>Fluorescence spectroscopy</topic><topic>Insight</topic><topic>Ligands</topic><topic>Microscopy</topic><topic>Molecular dynamics</topic><topic>Neurons</topic><topic>Neuroplasticity</topic><topic>Neuroscience</topic><topic>Neurotransmission</topic><topic>postsynaptic density</topic><topic>Postsynaptic density proteins</topic><topic>protein dynamics</topic><topic>Proteins</topic><topic>Signal transduction</topic><topic>Simulation</topic><topic>Simulation methods</topic><topic>single molecule fluorescence</topic><topic>single-molecule FRET</topic><topic>Structural Biology and Molecular Biophysics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maslov, Ivan</creatorcontrib><creatorcontrib>Hendrix, Jelle</creatorcontrib><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>eLife</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maslov, Ivan</au><au>Hendrix, Jelle</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Unmasking a two-faced protein</atitle><jtitle>eLife</jtitle><date>2022-10-19</date><risdate>2022</risdate><volume>11</volume><issn>2050-084X</issn><eissn>2050-084X</eissn><abstract>Single-molecule fluorescence spectroscopy and molecular dynamics simulations illuminate the structure and dynamics of PSD-95, a protein involved in neural plasticity.</abstract><cop>Cambridge</cop><pub>eLife Science Publications, Ltd</pub><doi>10.7554/eLife.83482</doi><orcidid>https://orcid.org/0000-0001-5731-1297</orcidid><orcidid>https://orcid.org/0000-0003-3371-4416</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2050-084X
ispartof eLife, 2022-10, Vol.11
issn 2050-084X
2050-084X
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_505ca1b844ee40039b7f30aa418fadc4
source Publicly Available Content Database; PubMed Central
subjects Chemical bonds
Fluorescence spectroscopy
Insight
Ligands
Microscopy
Molecular dynamics
Neurons
Neuroplasticity
Neuroscience
Neurotransmission
postsynaptic density
Postsynaptic density proteins
protein dynamics
Proteins
Signal transduction
Simulation
Simulation methods
single molecule fluorescence
single-molecule FRET
Structural Biology and Molecular Biophysics
title Unmasking a two-faced protein
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T21%3A42%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Unmasking%20a%20two-faced%20protein&rft.jtitle=eLife&rft.au=Maslov,%20Ivan&rft.date=2022-10-19&rft.volume=11&rft.issn=2050-084X&rft.eissn=2050-084X&rft_id=info:doi/10.7554/eLife.83482&rft_dat=%3Cgale_doaj_%3EA723233258%3C/gale_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c511t-fae8a5be53c1d7a9e67f067e855243b4621d8fcd22ac8867aa8091dd03fcacc3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2730538506&rft_id=info:pmid/&rft_galeid=A723233258&rfr_iscdi=true