Recent Advances in Single-Molecule Sensors Based on STM Break Junction Measurements

Single-molecule recognition and detection with the highest resolution measurement has been one of the ultimate goals in science and engineering. Break junction techniques, originally developed to measure single-molecule conductance, recently have also been proven to have the capacity for the label-f...

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Bibliographic Details
Published in:Biosensors (Basel) 2022-07, Vol.12 (8), p.565
Main Authors: Lv, Shan-Ling, Zeng, Cong, Yu, Zhou, Zheng, Ju-Fang, Wang, Ya-Hao, Shao, Yong, Zhou, Xiao-Shun
Format: Article
Language:English
Subjects:
Adsorption
Biosensors
Design and construction
Electrical measurement
Electrodes
ionic detection
Methods
Microscopy
Molecular probes
Molecular structure
nucleotide detection
Peptides
pH detection
Review
Scanning microscopy
Selectivity
Sensors
single-molecule sensor
STM break junction
Temporal resolution
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Summary:Single-molecule recognition and detection with the highest resolution measurement has been one of the ultimate goals in science and engineering. Break junction techniques, originally developed to measure single-molecule conductance, recently have also been proven to have the capacity for the label-free exploration of single-molecule physics and chemistry, which paves a new way for single-molecule detection with high temporal resolution. In this review, we outline the primary advances and potential of the STM break junction technique for qualitative identification and quantitative detection at a single-molecule level. The principles of operation of these single-molecule electrical sensing mainly in three regimes, ion, environmental pH and genetic material detection, are summarized. It clearly proves that the single-molecule electrical measurements with break junction techniques show a promising perspective for designing a simple, label-free and nondestructive electrical sensor with ultrahigh sensitivity and excellent selectivity.
ISSN:2079-6374
2079-6374
DOI:10.3390/bios12080565