Molecular approaches for eco-epidemiological studies of Paracoccidioides brasiliensis

Medical mycology has greatly benefited from the introduction of molecular techniques. New knowledge on molecular genetics has provided both theoretical and practical frameworks, permitting important advances in our understanding of several aspects of pathogenic fungi. Considering Paracoccidioides br...

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Bibliographic Details
Published in:Memórias do Instituto Oswaldo Cruz 2009-07, Vol.104 (4), p.636-643
Main Authors: Richini-Pereira, Virgínia Bodelão, Bosco, Sandra de Moraes Gimenes, Theodoro, Raquel Cordeiro, Macoris, Severino Assis da Graça, Bagagli, Eduardo
Format: Article
Language:English
Subjects:
DNA, Fungal - genetics
DNA, Ribosomal - genetics
eco-epidemiology
Mycological Typing Techniques
Paracoccidioides - genetics
Paracoccidioides brasiliensis
Paracoccidioides brasiliensis - eco-epidemiology - PCR
PARASITOLOGY
PCR
Phylogeny
TROPICAL MEDICINE
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Summary:Medical mycology has greatly benefited from the introduction of molecular techniques. New knowledge on molecular genetics has provided both theoretical and practical frameworks, permitting important advances in our understanding of several aspects of pathogenic fungi. Considering Paracoccidioides brasiliensis in particular, important eco-epidemiological aspects, such as environmental distribution and new hosts were clarified through molecular approaches. These methodologies also contributed to a better understanding about the genetic variability of this pathogen; thus, P. brasiliensis is now assumed to represent a species complex. The present review focuses on some recent findings about the current taxonomic status of P. brasiliensis, its phylogenetic and speciation processes, as well as on some practical applications for the molecular detection of this pathogen in environmental and clinical materials.
ISSN:1678-8060
0074-0276
1678-8060
0074-0276
DOI:10.1590/S0074-02762009000400018