Advances in Mechanism Research on Polygonatum in Prevention and Treatment of Diabetes

Diabetes mellitus is a fast-growing disease with a major influence on people's quality of life. Oral hypoglycemic drugs and insulin are currently the main effective drugs in the treatment of diabetes, but chronic consumption of these drugs has certain side effects. Polysaccharides, saponins, fl...

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Bibliographic Details
Published in:Frontiers in pharmacology 2022-02, Vol.13, p.758501-758501
Main Authors: Liu, Shuang, Jia, Qiao-Jun, Peng, Yi-Qing, Feng, Ting-Hui, Hu, Shu-Ting, Dong, Juan-E, Liang, Zong-Suo
Format: Article
Language:English
Subjects:
antidiabetic mechanism
diabetes
hypoglycemic
hypolipidemic
Pharmacology
Polygonatum
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Summary:Diabetes mellitus is a fast-growing disease with a major influence on people's quality of life. Oral hypoglycemic drugs and insulin are currently the main effective drugs in the treatment of diabetes, but chronic consumption of these drugs has certain side effects. Polysaccharides, saponins, flavonoids, and phenolics are the primary secondary metabolites isolated from the rhizomes of Redouté [Asparagaceae], Collett & Hemsl [Asparagaceae], or Hua [Asparagaceae], which have attracted much more attention owing to their unique therapeutic role in the treatment and prevention of diabetes. However, the research on the mechanism of these three spp. in diabetes has not been reviewed. This review provides a summary of the research progress of three spp. on diabetes and its complications, reveals the potential antidiabetic mechanism of three spp., and discusses the effect of different processed products of three spp. in treating diabetes, for the sake of a thorough understanding of its effects on the prevention and treatment of diabetes and diabetes complications.
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2022.758501