The Association Between Folate and Alzheimer's Disease: A Systematic Review and Meta-Analysis

Alzheimer's disease (AD) is the most common type of neurodegenerative disease leading to dementia in the elderly. Increasing evidence indicates that folate plays an important role in the pathogenesis of AD. To investigate the role of folate deficiency/possible deficiency in the risk of AD and t...

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Bibliographic Details
Published in:Frontiers in neuroscience 2021-04, Vol.15, p.661198-661198
Main Authors: Zhang, Xiaohong, Bao, Guangyi, Liu, Debiao, Yang, Yu, Li, Xuezhi, Cai, Gaomei, Liu, Yan, Wu, Yili
Format: Article
Language:English
Subjects:
Age
Alzheimer's disease
Dementia
Dementia disorders
Disease prevention
folate deficiency
folate level
Folic acid
Intervention
meta-analaysis
Meta-analysis
Neurodegenerative diseases
Neuroscience
Plasma
Sensitivity analysis
sufficient folate intake
Survival analysis
Systematic review
Vitamin B
Vitamin deficiency
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Summary:Alzheimer's disease (AD) is the most common type of neurodegenerative disease leading to dementia in the elderly. Increasing evidence indicates that folate plays an important role in the pathogenesis of AD. To investigate the role of folate deficiency/possible deficiency in the risk of AD and the benefical effect of sufficient folate intake on the prevention of AD, a systematic review and meta-analysis were performed. The Web of Science, PubMed, CENTRAL, EBSCO, CNKI, CQVIP, and Wanfang databases were searched. The analysis of cross-sectional studies showed that the standardized mean difference (SMD) was -0.60 (95% confidence interval (CI): -0.65, -0.55), indicating that plasma/serum folate level is lower in AD patients than that in controls. Moreover, the combined odds ratio (OR) of case-control studies was 0.96 (95% CI: 0.93, 0.99), while the combined ORs were 0.86 (95% CI: 0.46, 1.26) and 1.94 (95% CI: 1.02, 2.86) in populations with normal levels of folate (≥13.5 nmol/L) and folate deficiency/possible deficiency (
ISSN:1662-4548
1662-453X
1662-453X
DOI:10.3389/fnins.2021.661198