Diagnostic and prognostic biomarkers in immune checkpoint inhibitor-related encephalitis: a retrospective cohort studyResearch in context

Background: Immune checkpoint inhibitor-related encephalitis (ICI-encephalitis) is not well characterised and diagnostic and prognostic biomarkers are lacking. We aimed to comprehensively characterise ICI-encephalitis and identify diagnostic biomarkers and outcome predictors. Methods: This retrospec...

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Published in:The Lancet regional health. Europe 2024-09, Vol.44, p.101011
Main Authors: Antonio Farina, Macarena Villagrán-García, Anthony Fourier, Anne-Laurie Pinto, Fatima Chorfa, Noémie Timestit, Tifanie Alberto, Jérôme Aupy, Marie Benaiteau, Cristina Birzu, Lucia Campetella, François Cotton, Stéphane Dalle, Clara Fontaine Delaruelle, Pauline Dumez, Rafaele Germi, Marion Le Maréchal, Denis Maillet, Romain Marignier, Antoine Pegat, Dimitri Psimaras, Marie Rafiq, Géraldine Picard, Virginie Desestret, Isabelle Quadrio, Jérôme Honnorat, Bastien Joubert
Format: Article
Language:English
Subjects:
Adverse events
Autoimmune encephalitis
Cancer immunotherapy
Encephalitis
Immune checkpoint inhibitors
Neurological immune-related adverse events
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Summary:Background: Immune checkpoint inhibitor-related encephalitis (ICI-encephalitis) is not well characterised and diagnostic and prognostic biomarkers are lacking. We aimed to comprehensively characterise ICI-encephalitis and identify diagnostic biomarkers and outcome predictors. Methods: This retrospective observational study included all patients with ICI-encephalitis studied in the French Reference Centre on Paraneoplastic Neurological Syndromes (PNS) and Autoimmune Encephalitis (2015–2023). ICI encephalitis was considered definite in case of inflammatory findings at paraclinical tests and/or well-characterised neural antibodies. Predictors of immune-related adverse event (irAE) treatment response, defined as a Common Terminology Criteria for Adverse Events v5.0 grade 
ISSN:2666-7762