Synthesis and biological evaluation of new benzofuran carboxamide derivatives

A series of new 3-(glycinamido)-benzofuran-2-carboxamide and 3-(β-alanamido)-benzofuran-2-carboxamide derivatives (5a–o) were synthesized for the purpose of developing the new bioactive chemical entities and evaluated for their in vitro antimicrobial, anti-inflammatory and DPPH radical scavenging ac...

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Bibliographic Details
Published in:Journal of Saudi Chemical Society 2017-03, Vol.21 (3), p.277-285
Main Authors: Lavanya, Andiappan, Sribalan, Rajendran, Padmini, Vediappen
Format: Article
Language:English
Subjects:
Anti-inflammatory
Antimicrobial
Antioxidant
Benzofuran
Carboxamide
Glycinamide
β-Alanamide
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Summary:A series of new 3-(glycinamido)-benzofuran-2-carboxamide and 3-(β-alanamido)-benzofuran-2-carboxamide derivatives (5a–o) were synthesized for the purpose of developing the new bioactive chemical entities and evaluated for their in vitro antimicrobial, anti-inflammatory and DPPH radical scavenging activities. The synthesized compounds were characterized by NMR, IR, Mass and X-ray crystallographic techniques.
ISSN:1319-6103
DOI:10.1016/j.jscs.2015.06.008