Auditory evoked potentials in a newborn Wistar rat model of hyperbilirubinemia

Hyperbilirubinemia is a common health problem in newborns. Its effects can be different according to the level and duration of the hyperbilirubinemia. The toxic effect of bilirubin on the auditory system can be seen as a sensory neural hearing loss or auditory neuropathy spectrum disorder (ANSD). Th...

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Bibliographic Details
Published in:Brazilian journal of otorhinolaryngology 2016-03, Vol.82 (2), p.144-150
Main Authors: Gökdoğan, Çağıl, Genç, Aydan, Gülbahar, Özlem, Gökdoğan, Ozan, Helvacı, Ayşe, Bezgin, Selin Üstün, Memiş, Leyla
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Audiometry
Auditory evoked potentials
Deficiência auditiva neurosensorial
Disease Models, Animal
Evoked Potentials, Auditory - physiology
Evoked Potentials, Auditory, Brain Stem - physiology
Hearing Loss, Sensorineural - etiology
Hearing Loss, Sensorineural - physiopathology
Hiperbilirrubinemia
Hyperbilirubinemia
Hyperbilirubinemia, Neonatal - complications
Hyperbilirubinemia, Neonatal - physiopathology
Male
Original
OTORHINOLARYNGOLOGY
Potenciais evocados auditivos
Ratos Wistar
Rats
Rats, Wistar
Sensorineural hearing loss
Wistar rats
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Summary:Hyperbilirubinemia is a common health problem in newborns. Its effects can be different according to the level and duration of the hyperbilirubinemia. The toxic effect of bilirubin on the auditory system can be seen as a sensory neural hearing loss or auditory neuropathy spectrum disorder (ANSD). The purpose of our study was to determine the effects of toxic bilirubin level on the auditory system by using Auditory Brainstem Response audiometry. Rats are used as animal models due to their low cost and easy attainability. Auditory Brainstem Response was used for auditory assessment. In this study, three groups were established: experimental, control and placebo groups. In the experimental group, which consists of rats with hyperbilirubinemia, sensory neural hearing loss was found bilaterally in 4 rats (66.67%) and unilaterally in 2 rats (16.67%) and auditory neuropathy spectrum disorder was found unilaterally in 1 rat (8.33%). Auditory Brainstem Response thresholds were significantly elevated compared to control and placebo groups (p
ISSN:1808-8694
1808-8686
1808-8686
DOI:10.1016/j.bjorl.2015.10.008