Effects of enoxaparin and unfractionated heparin in prophylactic and therapeutic doses on the fertility of female Wistar rats

PURPOSE: To evaluate the effects of exposure of enoxaparin and unfractionated heparin (UFH) in prophylactic and therapeutic doses on the fertility rates of pregnant healthy Wistar rats.METHODS:Enoxaparin and UFH were administered in prophylactic doses 1 mg/Kg/day 72 UI/Kg/day, and in therapeutic dos...

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Published in:Acta cirúrgica brasileira 2014-07, Vol.29 (7), p.410-416
Main Authors: Figueiró-Filho, Ernesto Antonio, Aydos, Ricardo Dutra, Senefonte, Flávio Renato de Almeida, Ferreira, Cristiane Munaretto, Pereira, Érica Freire de Vasconcelos, Oliveira, Vanessa Marcon de, Menezes, Giovanna Pádoa de, Bósio, Marco Antonio Costa
Format: Article
Language:English
Subjects:
Enoxaparin
Fertility
Heparin
Pregnancy
Rats
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Summary:PURPOSE: To evaluate the effects of exposure of enoxaparin and unfractionated heparin (UFH) in prophylactic and therapeutic doses on the fertility rates of pregnant healthy Wistar rats.METHODS:Enoxaparin and UFH were administered in prophylactic doses 1 mg/Kg/day 72 UI/Kg/day, and in therapeutic doses at 2 mg/kg/day 400UI/Kg/day. The rats were divided into five groups. The number of live and dead foetuses was quantified. The uterine horns were dissected and the presence of early and late reabsorptions (abortions) was determined. A p
ISSN:0102-8650
0102-8650
DOI:10.1590/S0102-86502014000700001