PC-PEP, a Comprehensive Daily Six-Month Home-Based Patient Empowerment Program Leads to Weight Loss in Men with Prostate Cancer: A Secondary Analysis of a Clinical Trial

The Prostate Cancer-Patient Empowerment Program (PC-PEP) is a six-month daily home-based program shown to improve mental health and urinary function. This secondary analysis explores weight loss in male PC-PEP participants. In a randomized clinical trial with 128 men undergoing curative prostate can...

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Bibliographic Details
Published in:Current oncology (Toronto) 2024-03, Vol.31 (3), p.1667-1688
Main Authors: MacNevin, Wyatt, Ilie, Gabriela, Rendon, Ricardo, Mason, Ross, Spooner, Jesse, Chedrawe, Emily, Patil, Nikhilesh, Bowes, David, Bailly, Greg, Bell, David, Wilke, Derek, Zahavich, Jeffery B L, MacDonald, Cody, Rutledge, Robert David Harold
Format: Article
Language:English
Subjects:
Body weight
Cancer
Cancer patients
Care and treatment
curative treatment
Exercise
exercise intervention
Exercise Therapy
Humans
Male
Mental health
Nutrition
Patient Participation
Prostate cancer
Prostatic Neoplasms - therapy
radiation
radical prostatectomy
Requirements
Weight Loss
Weight training
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Summary:The Prostate Cancer-Patient Empowerment Program (PC-PEP) is a six-month daily home-based program shown to improve mental health and urinary function. This secondary analysis explores weight loss in male PC-PEP participants. In a randomized clinical trial with 128 men undergoing curative prostate cancer (PC) treatment, 66 received 'early' PC-PEP, while 62 were assigned to the 'late' waitlist-control group, receiving 6 months of standard-of-care treatment followed by 6 months of PC-PEP. PC-PEP comprised 182 daily emails with video-based exercise and dietary (predominantly plant-based) education, live online events, and 30 min strength training routines (using body weight and elastic bands). Weight and height data were collected via online surveys (baseline, 6 months, and 12 months) including medical chart reviews. Adherence was tracked weekly. No attrition or adverse events were reported. At 6 months, the early PC-PEP group experienced significant weight loss, averaging 2.7 kg ( < 0.001) compared to the waitlist-control group. Weight loss was noted in the late intervention group of PC-PEP, albeit less pronounced than in the early group. Early PC-PEP surgery patients lost on average 1.4 kg (SE = 0.65) from the trial's start to surgery day. High adherence to exercise and dietary recommendations was noted. PC-PEP led to significant weight loss in men undergoing curative prostate cancer treatment compared to standard-of-care.
ISSN:1718-7729
1198-0052
1718-7729
DOI:10.3390/curroncol31030127