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PC-PEP, a Comprehensive Daily Six-Month Home-Based Patient Empowerment Program Leads to Weight Loss in Men with Prostate Cancer: A Secondary Analysis of a Clinical Trial
The Prostate Cancer-Patient Empowerment Program (PC-PEP) is a six-month daily home-based program shown to improve mental health and urinary function. This secondary analysis explores weight loss in male PC-PEP participants. In a randomized clinical trial with 128 men undergoing curative prostate can...
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| Published in: | Current oncology (Toronto) 2024-03, Vol.31 (3), p.1667-1688 |
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| container_title | Current oncology (Toronto) |
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| creator | MacNevin, Wyatt Ilie, Gabriela Rendon, Ricardo Mason, Ross Spooner, Jesse Chedrawe, Emily Patil, Nikhilesh Bowes, David Bailly, Greg Bell, David Wilke, Derek Zahavich, Jeffery B L MacDonald, Cody Rutledge, Robert David Harold |
| description | The Prostate Cancer-Patient Empowerment Program (PC-PEP) is a six-month daily home-based program shown to improve mental health and urinary function. This secondary analysis explores weight loss in male PC-PEP participants.
In a randomized clinical trial with 128 men undergoing curative prostate cancer (PC) treatment, 66 received 'early' PC-PEP, while 62 were assigned to the 'late' waitlist-control group, receiving 6 months of standard-of-care treatment followed by 6 months of PC-PEP. PC-PEP comprised 182 daily emails with video-based exercise and dietary (predominantly plant-based) education, live online events, and 30 min strength training routines (using body weight and elastic bands). Weight and height data were collected via online surveys (baseline, 6 months, and 12 months) including medical chart reviews. Adherence was tracked weekly.
No attrition or adverse events were reported. At 6 months, the early PC-PEP group experienced significant weight loss, averaging 2.7 kg (
< 0.001) compared to the waitlist-control group. Weight loss was noted in the late intervention group of PC-PEP, albeit less pronounced than in the early group. Early PC-PEP surgery patients lost on average 1.4 kg (SE = 0.65) from the trial's start to surgery day. High adherence to exercise and dietary recommendations was noted.
PC-PEP led to significant weight loss in men undergoing curative prostate cancer treatment compared to standard-of-care. |
| doi_str_mv | 10.3390/curroncol31030127 |
| format | article |
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In a randomized clinical trial with 128 men undergoing curative prostate cancer (PC) treatment, 66 received 'early' PC-PEP, while 62 were assigned to the 'late' waitlist-control group, receiving 6 months of standard-of-care treatment followed by 6 months of PC-PEP. PC-PEP comprised 182 daily emails with video-based exercise and dietary (predominantly plant-based) education, live online events, and 30 min strength training routines (using body weight and elastic bands). Weight and height data were collected via online surveys (baseline, 6 months, and 12 months) including medical chart reviews. Adherence was tracked weekly.
No attrition or adverse events were reported. At 6 months, the early PC-PEP group experienced significant weight loss, averaging 2.7 kg (
< 0.001) compared to the waitlist-control group. Weight loss was noted in the late intervention group of PC-PEP, albeit less pronounced than in the early group. Early PC-PEP surgery patients lost on average 1.4 kg (SE = 0.65) from the trial's start to surgery day. High adherence to exercise and dietary recommendations was noted.
PC-PEP led to significant weight loss in men undergoing curative prostate cancer treatment compared to standard-of-care.</description><identifier>ISSN: 1718-7729</identifier><identifier>ISSN: 1198-0052</identifier><identifier>EISSN: 1718-7729</identifier><identifier>DOI: 10.3390/curroncol31030127</identifier><identifier>PMID: 38534960</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Body weight ; Cancer ; Cancer patients ; Care and treatment ; curative treatment ; Exercise ; exercise intervention ; Exercise Therapy ; Humans ; Male ; Mental health ; Nutrition ; Patient Participation ; Prostate cancer ; Prostatic Neoplasms - therapy ; radiation ; radical prostatectomy ; Requirements ; Weight Loss ; Weight training</subject><ispartof>Current oncology (Toronto), 2024-03, Vol.31 (3), p.1667-1688</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c485t-4d17f682bd9b93b8e017118057954edd973a82a3a076cba499a1752bdf6dfca13</cites><orcidid>0000-0002-1602-6374 ; 0009-0007-1962-6635 ; 0000-0001-8082-5018</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10969418/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10969418/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38534960$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MacNevin, Wyatt</creatorcontrib><creatorcontrib>Ilie, Gabriela</creatorcontrib><creatorcontrib>Rendon, Ricardo</creatorcontrib><creatorcontrib>Mason, Ross</creatorcontrib><creatorcontrib>Spooner, Jesse</creatorcontrib><creatorcontrib>Chedrawe, Emily</creatorcontrib><creatorcontrib>Patil, Nikhilesh</creatorcontrib><creatorcontrib>Bowes, David</creatorcontrib><creatorcontrib>Bailly, Greg</creatorcontrib><creatorcontrib>Bell, David</creatorcontrib><creatorcontrib>Wilke, Derek</creatorcontrib><creatorcontrib>Zahavich, Jeffery B L</creatorcontrib><creatorcontrib>MacDonald, Cody</creatorcontrib><creatorcontrib>Rutledge, Robert David Harold</creatorcontrib><title>PC-PEP, a Comprehensive Daily Six-Month Home-Based Patient Empowerment Program Leads to Weight Loss in Men with Prostate Cancer: A Secondary Analysis of a Clinical Trial</title><title>Current oncology (Toronto)</title><addtitle>Curr Oncol</addtitle><description>The Prostate Cancer-Patient Empowerment Program (PC-PEP) is a six-month daily home-based program shown to improve mental health and urinary function. This secondary analysis explores weight loss in male PC-PEP participants.
In a randomized clinical trial with 128 men undergoing curative prostate cancer (PC) treatment, 66 received 'early' PC-PEP, while 62 were assigned to the 'late' waitlist-control group, receiving 6 months of standard-of-care treatment followed by 6 months of PC-PEP. PC-PEP comprised 182 daily emails with video-based exercise and dietary (predominantly plant-based) education, live online events, and 30 min strength training routines (using body weight and elastic bands). Weight and height data were collected via online surveys (baseline, 6 months, and 12 months) including medical chart reviews. Adherence was tracked weekly.
No attrition or adverse events were reported. At 6 months, the early PC-PEP group experienced significant weight loss, averaging 2.7 kg (
< 0.001) compared to the waitlist-control group. Weight loss was noted in the late intervention group of PC-PEP, albeit less pronounced than in the early group. Early PC-PEP surgery patients lost on average 1.4 kg (SE = 0.65) from the trial's start to surgery day. High adherence to exercise and dietary recommendations was noted.
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This secondary analysis explores weight loss in male PC-PEP participants.
In a randomized clinical trial with 128 men undergoing curative prostate cancer (PC) treatment, 66 received 'early' PC-PEP, while 62 were assigned to the 'late' waitlist-control group, receiving 6 months of standard-of-care treatment followed by 6 months of PC-PEP. PC-PEP comprised 182 daily emails with video-based exercise and dietary (predominantly plant-based) education, live online events, and 30 min strength training routines (using body weight and elastic bands). Weight and height data were collected via online surveys (baseline, 6 months, and 12 months) including medical chart reviews. Adherence was tracked weekly.
No attrition or adverse events were reported. At 6 months, the early PC-PEP group experienced significant weight loss, averaging 2.7 kg (
< 0.001) compared to the waitlist-control group. Weight loss was noted in the late intervention group of PC-PEP, albeit less pronounced than in the early group. Early PC-PEP surgery patients lost on average 1.4 kg (SE = 0.65) from the trial's start to surgery day. High adherence to exercise and dietary recommendations was noted.
PC-PEP led to significant weight loss in men undergoing curative prostate cancer treatment compared to standard-of-care.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>38534960</pmid><doi>10.3390/curroncol31030127</doi><tpages>22</tpages><orcidid>https://orcid.org/0000-0002-1602-6374</orcidid><orcidid>https://orcid.org/0009-0007-1962-6635</orcidid><orcidid>https://orcid.org/0000-0001-8082-5018</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Body weight Cancer Cancer patients Care and treatment curative treatment Exercise exercise intervention Exercise Therapy Humans Male Mental health Nutrition Patient Participation Prostate cancer Prostatic Neoplasms - therapy radiation radical prostatectomy Requirements Weight Loss Weight training |
| title | PC-PEP, a Comprehensive Daily Six-Month Home-Based Patient Empowerment Program Leads to Weight Loss in Men with Prostate Cancer: A Secondary Analysis of a Clinical Trial |
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