Triglyceride-mediated influence of serum angiopoietin-like protein 8 on subclinical atherosclerosis in type 2 diabetic patients: results from the GDMD study in China

Hypertriglyceridemia, insulin resistance and hyperglycemia are risk factors for atherosclerosis in type 2 diabetes. Angiopoietin-like protein 8 (ANGPTL8) is a newly identified liver-derived hormone related to these risk factors. Hence, we aimed to explore the correlations between serum levels of ANG...

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Bibliographic Details
Published in:Cardiovascular diabetology 2018-07, Vol.17 (1), p.84-84, Article 84
Main Authors: Zheng, Tianpeng, Ge, Bo, Liu, Hongbo, Chen, Bo, Qin, Linyuan, Xiao, Liuping, Song, Jianfei
Format: Article
Language:English
Subjects:
Aged
Angiopoietin
Angiopoietin-like Proteins - blood
ANGPTL8
Arteriosclerosis
Atherosclerosis
Bioindicators
Biomarkers - blood
Blood glucose
Blood Glucose - analysis
Carotid arteries
Carotid artery
Carotid Artery Diseases - blood
Carotid Artery Diseases - diagnostic imaging
Carotid Artery Diseases - epidemiology
Carotid Intima-Media Thickness
Case-Control Studies
China - epidemiology
Cross-Sectional Studies
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - diagnosis
Diabetes Mellitus, Type 2 - epidemiology
Diabetic retinopathy
Female
Glucose
Homeostasis
Humans
Hyperglycemia
Hypertriglyceridemia
Hypertriglyceridemia - blood
Hypertriglyceridemia - diagnosis
Hypertriglyceridemia - epidemiology
Insulin
Insulin resistance
Lipids
Liver
Male
Measurement methods
Metabolic syndrome
Middle Aged
Original Investigation
Pathogenesis
Peptide Hormones - blood
Proteins
Regression analysis
Risk Factors
Serum levels
Triglyceride
Triglycerides - blood
Type 2 diabetes
Variables
Veins & arteries
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Summary:Hypertriglyceridemia, insulin resistance and hyperglycemia are risk factors for atherosclerosis in type 2 diabetes. Angiopoietin-like protein 8 (ANGPTL8) is a newly identified liver-derived hormone related to these risk factors. Hence, we aimed to explore the correlations between serum levels of ANGPTL8 and subclinical atherosclerosis in type 2 diabetes. We measured serum ANGPTL8, blood lipids, blood glucose, common carotid artery Intima-Media Thickness (c-IMT) and calculated homeostasis model assessment of insulin resistance in (1) control subjects (n = 100), (2) type 2 diabetic patients without subclinical atherosclerosis (n = 100), and (3) type 2 diabetic patients with subclinical atherosclerosis (n = 100). Serum levels of ANGPTL8 and triglyceride (TG) were significantly increased in type 2 diabetic patients with subclinical atherosclerosis as compared with type 2 diabetic patients without subclinical atherosclerosis and control subjects (P 
ISSN:1475-2840
1475-2840
DOI:10.1186/s12933-018-0687-y