Cerebral Degeneration in Amyotrophic Lateral Sclerosis Revealed by 3-Dimensional Texture Analysis

Routine MR images do not consistently reveal pathological changes in the brain in ALS. Texture analysis, a method to quantitate voxel intensities and their patterns and interrelationships, can detect changes in images not apparent to the naked eye. Our objective was to evaluate cerebral degeneration...

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Bibliographic Details
Published in:Frontiers in neuroscience 2016-03, Vol.10, p.120-120
Main Authors: Maani, Rouzbeh, Yang, Yee-Hong, Emery, Derek, Kalra, Sanjay
Format: Article
Language:English
Subjects:
Alzheimer's disease
Amyotrophic Lateral Sclerosis
biomarker
cerebral degeneration
Methods
Motor task performance
MRI
Multiple sclerosis
Neurodegeneration
NMR
Nuclear magnetic resonance
Precentral gyrus
Psychiatry
Pyramidal tracts
Spectrum analysis
Statistical analysis
Temporal lobe
Texture Analysis
Thalamus
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Summary:Routine MR images do not consistently reveal pathological changes in the brain in ALS. Texture analysis, a method to quantitate voxel intensities and their patterns and interrelationships, can detect changes in images not apparent to the naked eye. Our objective was to evaluate cerebral degeneration in ALS using 3-dimensional texture analysis of MR images of the brain. In a case-control design, voxel-based texture analysis was performed on T1-weighted MR images of 20 healthy subjects and 19 patients with ALS. Four texture features, namely, autocorrelation, sum of squares variance, sum average, and sum variance were computed. Texture features were compared between the groups by statistical parametric mapping and correlated with clinical measures of disability and upper motor neuron dysfunction. Texture features were different in ALS in motor regions including the precentral gyrus and corticospinal tracts. To a lesser extent, changes were also found in the thalamus, cingulate gyrus, and temporal lobe. Texture features in the precentral gyrus correlated with disease duration, and in the corticospinal tract they correlated with finger tapping speed. Changes in MR image textures are present in motor and non-motor regions in ALS and correlate with clinical features. Whole brain texture analysis has potential in providing biomarkers of cerebral degeneration in ALS.
ISSN:1662-4548
1662-453X
1662-453X
DOI:10.3389/fnins.2016.00120