pH-Responsive Super-Porous Hybrid Hydrogels for Gastroretentive Controlled-Release Drug Delivery

Super-porous hydrogels are considered a potential drug delivery network for the sedation of gastric mechanisms with retention windows in the abdomen and upper part of the gastrointestinal tract (GIT). In this study, a novel pH-responsive super-porous hybrid hydrogels (SPHHs) was synthesized from pec...

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Bibliographic Details
Published in:Pharmaceutics 2023-03, Vol.15 (3), p.816
Main Authors: Juthi, Ajkia Zaman, Li, Fenfen, Wang, Bo, Alam, Md Mofasserul, Talukder, Md Eman, Qiu, Bensheng
Format: Article
Language:English
Subjects:
Controlled release technology
controlled-release drug delivery
Drug delivery systems
Ethanol
Gastrointestinal system
gastroretentive
Gels (Pharmacy)
Hydrogels
Materials
Mechanical properties
Physiological aspects
Polymerization
Polymers
super-porous hybrid hydrogels
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Summary:Super-porous hydrogels are considered a potential drug delivery network for the sedation of gastric mechanisms with retention windows in the abdomen and upper part of the gastrointestinal tract (GIT). In this study, a novel pH-responsive super-porous hybrid hydrogels (SPHHs) was synthesized from pectin, poly 2-hydroxyethyl methacrylate (2HEMA), and N, N methylene-bis-acrylamide (BIS) via the gas-blowing technique, and then loaded with a selected drug (amoxicillin trihydrate, AT) at pH 5 via an aqueous loading method. The drug-loaded SPHHs-AT carrier demonstrated outstanding (in vitro) gastroretentive drug delivery capability. The study attributed excellent swelling and delayed drug release to acidic conditions at pH 1.2. Moreover, in vitro controlled-release drug delivery systems at different pH values, namely, 1.2 (97.99%) and 7.4 (88%), were studied. These exceptional features of SPHHs-improved elasticity, pH responsivity, and high swelling performance-should be investigated for broader drug delivery applications in the future.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics15030816