Gene flow mediates the role of sex chromosome meiotic drive during complex speciation

During speciation, sex chromosomes often accumulate interspecific genetic incompatibilities faster than the rest of the genome. The drive theory posits that sex chromosomes are susceptible to recurrent bouts of meiotic drive and suppression, causing the evolutionary build-up of divergent cryptic sex...

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Bibliographic Details
Published in:eLife 2018-12, Vol.7
Main Authors: Meiklejohn, Colin D, Landeen, Emily L, Gordon, Kathleen E, Rzatkiewicz, Thomas, Kingan, Sarah B, Geneva, Anthony J, Vedanayagam, Jeffrey P, Muirhead, Christina A, Garrigan, Daniel, Stern, David L, Presgraves, Daven C
Format: Article
Language:English
Subjects:
Animals
Biological Evolution
Chromosomes
Divergence
Drosophila - genetics
Drosophila mauritiana
Drosophila simulans
Drosophila simulans - genetics
Evolution
Evolutionary Biology
Gene Flow
Gene mapping
Genes
Genetic Speciation
Genetics and Genomics
Genomics
Haplotypes
Hypotheses
Infertility, Male - genetics
Insects
Interspecific
Male
Male sterility
Meiosis
Meiosis - genetics
Meiotic drive
Population
Sex chromosomes
Sex linkage
Speciation
Species Specificity
X Chromosome - genetics
Y Chromosome - genetics
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Summary:During speciation, sex chromosomes often accumulate interspecific genetic incompatibilities faster than the rest of the genome. The drive theory posits that sex chromosomes are susceptible to recurrent bouts of meiotic drive and suppression, causing the evolutionary build-up of divergent cryptic sex-linked drive systems and, incidentally, genetic incompatibilities. To assess the role of drive during speciation, we combine high-resolution genetic mapping of X-linked hybrid male sterility with population genomics analyses of divergence and recent gene flow between the fruitfly species, and . Our findings reveal a high density of genetic incompatibilities and a corresponding dearth of gene flow on the X chromosome. Surprisingly, we find that a known drive element recently migrated between species and, rather than contributing to interspecific divergence, caused a strong reduction in local sequence divergence, undermining the evolution of hybrid sterility. Gene flow can therefore mediate the effects of selfish genetic elements during speciation.
ISSN:2050-084X
2050-084X
DOI:10.7554/eLife.35468