Aerobic exercise improves motor dysfunction in Parkinson's model mice via differential regulation of striatal medium spiny neuron

• Published in: Scientific reports 2024-05, Vol.14 (1), p.12132-12132, Article 12132
• Main Authors: Wang, Yinhao, Wei, Longwei, Tan, Mingli, Yang, Zizheng, Gao, Bo, Li, Juan, Liu, Yang, Zikereya, Talifu, Shi, Kaixuan, Chen, Wei
• Format: Article
• Language: English
• Subjects: 631/378; 631/378/1689; 631/378/2632; Aerobic exercise; Aerobics; Animal models; Animals; Basal ganglia; Corpus Striatum - metabolism; D2-MSNs; Disease Models, Animal; Dopamine; Dopamine D2 receptors; Exercise; Firing rate; Humanities and Social Sciences; Male; Medium Spiny Neurons; Mice; Mice, Inbred C57BL; Molecular biology; Motor Activity - physiology; Motor dysfunctions; Movement disorders; multidisciplinary; Neostriatum; Neurodegenerative diseases; Neurons - metabolism; Neuroprotection; Parkinson Disease - metabolism; Parkinson Disease - physiopathology; Parkinson Disease - therapy; Parkinson's disease; Physical Conditioning, Animal; Physical fitness; Receptors, Dopamine D2 - genetics; Receptors, Dopamine D2 - metabolism; Science; Science (multidisciplinary); Spiny neurons; Striatum; Training
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-024-63045-4

The striatum plays a crucial role in providing input to the basal ganglia circuit and is implicated in the pathological process of Parkinson’s disease (PD). Disruption of the dynamic equilibrium in the basal ganglia loop can be attributed to the abnormal functioning of the medium spiny neurons (MSNs) within the striatum, potentially acting as a trigger for PD. Exercise has been shown to mitigate striatal neuronal dysfunction through neuroprotective and neurorestorative effects and to improve behavioral deficits in PD model mice. In addition, this effect is offset by the activation of MSNs expressing dopamine D2 receptors (D2-MSNs). In the current study, we investigated the underlying neurobiological mechanisms of this effect. Our findings indicated that exercise reduces the power spectral density of the beta-band in the striatum and decreases the overall firing frequency of MSNs, particularly in the case of striatal D2-MSNs. These observations were consistent with the results of molecular biology experiments, which revealed that aerobic training specifically enhanced the expression of striatal dopamine D2 receptors (D 2 R). Taken together, our results suggest that aerobic training aimed at upregulating striatal D 2 R expression to inhibit the functional activity of D2-MSNs represents a potential therapeutic strategy for the amelioration of motor dysfunction in PD.