Lower Adherence to Clotting Factor Replacement Therapy in Patients with Haemophilia Associated with More Depressive Symptoms: Two Centers Cross-Sectional Study

The aim of this study was to examine the association of depressive symptoms with medication adherence levels in a combined sample from Croatia and Slovenia. Participants in the study were adult patients with haemophilia receiving prophylaxis or on-demand treatment (N = 109). Their age was between 18...

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Bibliographic Details
Published in:Studia psychologica 2022-04, Vol.64 (1), p.64-75
Main Authors: Butkovic, Ana, Bago, Martina, Preloznik Zupan, Irena, Faganel Kotnik, Barbara, Prga Borojevic, Ivana, Bacic Vrca, Vesna, Zupancic Salek, Silva
Format: Article
Language:English
Subjects:
Cardiovascular disease
Chronic illnesses
Complications and side effects
Cross-sectional studies
Depression, Mental
depressive symptoms
Disease prevention
Drug therapy
Hemophilia
Hospitalization
Life expectancy
medication adherence
Mental depression
Patient compliance
patients with haemophilia
Psychological research
Questionnaires
Sociodemographics
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Summary:The aim of this study was to examine the association of depressive symptoms with medication adherence levels in a combined sample from Croatia and Slovenia. Participants in the study were adult patients with haemophilia receiving prophylaxis or on-demand treatment (N = 109). Their age was between 18 and 73 years (M = 43.86, SD = 14.89). Self-reported medication adherence (implementation phase) was measured with The Validated Haemophilia Regimen Treatment Adherence Scale, while depressive symptoms were measured with Beck Depression Inventory II. Comparison of adherence scores using t-test indicated that participants using prophylaxis were more adherent than participants using on-demand treatment on total scale and time and plan subscales. In hierarchical regression analyses depressive symptoms were a significant predictor for the total score and time subscale after controlling for sociodemographic and clinical variables. Screening for depressive symptoms and improving medication adherence of patients using on-demand treatment is recommended.
ISSN:0039-3320
2585-8815
DOI:10.31577/sp.2022.01.839