Triiodothyronine levels in athyreotic pediatric patients during levothyroxine therapy

Levothyroxine (LT ) monotherapy is the current recommended approach for treating pediatric patients post-total thyroidectomy (TT) based on the assumption that peripheral conversion of thyroxine (T ) to triiodothyronine (T ) normalizes thyroid hormone levels. In adults, approximately 15% of post-TT p...

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Bibliographic Details
Published in:Frontiers in endocrinology (Lausanne) 2024-08, Vol.15, p.1443394
Main Authors: Baran, Julia, Isaza, Amber, Bojarsky, Mya, Alzoebie, Lama, Song, Minkeun, Halada, Stephen, Sisko, Lindsay, Gonzales, Stephanie, Mostoufi-Moab, Sogol, Bauer, Andrew J
Format: Article
Language:English
Subjects:
Adolescent
Child
combination therapy
Endocrinology
Female
Graves Disease - blood
Graves Disease - drug therapy
Graves Disease - surgery
Hormone Replacement Therapy - methods
Humans
hypothyroidism
levothyroxine
liothyronine
Male
pediatrics
Retrospective Studies
T4 monotherapy
Thyroid Function Tests
Thyroid Neoplasms - blood
Thyroid Neoplasms - drug therapy
Thyroid Neoplasms - surgery
Thyroidectomy
Thyrotropin - blood
Thyroxine - administration & dosage
Thyroxine - blood
Thyroxine - therapeutic use
Triiodothyronine - blood
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Summary:Levothyroxine (LT ) monotherapy is the current recommended approach for treating pediatric patients post-total thyroidectomy (TT) based on the assumption that peripheral conversion of thyroxine (T ) to triiodothyronine (T ) normalizes thyroid hormone levels. In adults, approximately 15% of post-TT patients on LT4 monotherapy have altered T :T ratios with ongoing debate in regard to the clinical impact with respect to health-related quality of life (hrQOL). The ability to normalize T and T levels on LT monotherapy for pediatric patients' post-TT is important but not previously described. This study reports data on T levels in athyreotic pediatric patients to determine if a similar cohort of patients exists on LT4 monotherapy targeting normalization of TSH (LT4 replacement) or suppression (LT4 suppression). Thyroid function tests (TFTs) were retrospectively extracted from medical charts for patients
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2024.1443394