Metabolomic profiling of overnight peritoneal dialysis effluents predicts the peritoneal equilibration test type

This study primarily aimed to evaluate whether peritoneal equilibration test (PET) results can be predicted through the metabolomic analysis of overnight peritoneal dialysis (PD) effluents. From a total of 125 patients, overnight PD effluents on the day of the first PET after PD initiation were anal...

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Published in:Scientific reports 2023-03, Vol.13 (1), p.3803-3803, Article 3803
Main Authors: Kim, Hyo Jin, Choo, Munki, Kwon, Hyuk Nam, Yoo, Kyung Don, Kim, Yunmi, Tsogbadrakh, Bodokhsuren, Kang, Eunjeong, Park, Sunghyouk, Oh, Kook-Hwan
Format: Article
Language:English
Subjects:
631/45/320
692/4022/1950/1724
Creatinine
Dextrose
Dialysis
Dialysis Solutions
Discriminant analysis
Effluents
Humanities and Social Sciences
Humans
Lactic Acid
Membrane Transport Proteins
Metabolites
Metabolomics
multidisciplinary
NMR
Nuclear magnetic resonance
Peritoneal Dialysis
Peritoneum
Science
Science (multidisciplinary)
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Summary:This study primarily aimed to evaluate whether peritoneal equilibration test (PET) results can be predicted through the metabolomic analysis of overnight peritoneal dialysis (PD) effluents. From a total of 125 patients, overnight PD effluents on the day of the first PET after PD initiation were analyzed. A modified 4.25% dextrose PET was performed, and the PET type was categorized according to the dialysate-to-plasma creatinine ratio at the 4-h dwell time during the PET as follows: high, high average, low average, or low transporter. Nuclear magnetic resonance (NMR)-based metabolomics was used to analyze the effluents and identify the metabolites. The predictive performances derived from the orthogonal projection to latent structure discriminant analysis (OPLS-DA) modeling of the NMR spectrum were estimated by calculating the area under the curve (AUC) using receiver operating characteristic curve analysis. The OPLS-DA score plot indicated significant metabolite differences between high and low PET types. The relative concentrations of alanine and creatinine were greater in the high transporter type than in the low transporter type. The relative concentrations of glucose and lactate were greater in the low transporter type than in the high transporter type. The AUC of a composite of four metabolites was 0.975 in distinguish between high and low PET types. Measured PET results correlated well with the total NMR metabolic profile of overnight PD effluents.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-29741-3