Plasma cell type Castleman's disease of lacrimal gland: a case report and literature review

Orbital Castleman's disease is a rare benign lymphoproliferative disorder of extranodal origin. A 72-year-old man presented with bilateral upper eyelid swelling. Radiology revealed enlarged lacrimal glands in both eyes. Castleman's disease (plasma cell type) was confirmed by histo-immunoch...

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Bibliographic Details
Published in:BMC ophthalmology 2024-11, Vol.24 (1), p.508-6, Article 508
Main Authors: Xu, Liangyuan, Li, Jing, Xu, Xiaolin, Ren, Tingting, Ma, Jianmin
Format: Article
Language:English
Subjects:
Aged
B cells
Biopsy
Case Report
Case reports
Castleman Disease - diagnosis
Castleman Disease - pathology
Castleman's disease
Diplopia
Exocrine glands
Eye diseases
Eyelid
Follicles
Hepatitis
HIV
Human immunodeficiency virus
Humans
Hyperplasia
Immunoglobulin G
Lacrimal Apparatus - diagnostic imaging
Lacrimal Apparatus - pathology
Lacrimal Apparatus Diseases - diagnosis
Lacrimal Apparatus Diseases - pathology
Lacrimal Apparatus Diseases - surgery
Lacrimal gland
Lacrimal gland and Nasolacrimal duct
Literature reviews
Lymphatic system
Lymphocytes
Lymphoma
Magnetic Resonance Imaging
Male
Orbit
Pathology
Patients
Plasma
Plasma cell type
Plasma Cells - pathology
Radiation therapy
Steroids
Tomography, X-Ray Computed
Visual acuity
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Summary:Orbital Castleman's disease is a rare benign lymphoproliferative disorder of extranodal origin. A 72-year-old man presented with bilateral upper eyelid swelling. Radiology revealed enlarged lacrimal glands in both eyes. Castleman's disease (plasma cell type) was confirmed by histo-immunochemical examinations after excision of the left orbital mass. No extraorbital involvement was found in systemic evaluation. Postoperatively, corticosteroid therapy was given. After 1 year of follow-up, there was no recurrence in the left orbit, and the swelling of the right eyelid was improved. Here, we report a case of orbital Castleman's disease involving the lacrimal gland bilaterally and summarize previously reported cases. For bilateral orbital masses, the possibility of Castleman's disease should be considered. Before the diagnosis, it is necessary to fully distinguish from other diseases such as IgG4-related eye diseases.
ISSN:1471-2415
1471-2415
DOI:10.1186/s12886-024-03775-1