Immunoregulatory Effects of Bone Marrow-Derived Mesenchymal Stem Cells in the Nasal Polyp Microenvironment

Nasal polyposis is a severe, chronic inflammatory condition of the paranasal sinuses and is frequently associated with asthma and aspirin sensitivity. Mesenchymal stem cells exhibit a potent immunosuppressive effect in several inflammatory conditions, and their role in nasal polyposis remains little...

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Bibliographic Details
Published in:Mediators of Inflammation 2014-01, Vol.2014 (5), p.529-539
Main Authors: Pezato, Rogério, Almeida, Danilo Cândido de, Bezerra, Thiago Freire, Silva, Fernando de Sá, Perez-Novo, Claudina, Gregório, Luís Carlos, Voegels, Richard Louis, Câmara, Niels Olsen, Bachert, Claus
Format: Article
Language:English
Subjects:
Bone Marrow Cells - cytology
CD4-Positive T-Lymphocytes - cytology
CD8-Positive T-Lymphocytes - cytology
Cells, Cultured
Coculture Techniques
Cytokines - metabolism
Forkhead Transcription Factors - metabolism
Gene Expression Regulation
Genetic aspects
Health aspects
Humans
Identification and classification
Inflammation - immunology
Lymphocyte Activation
Medicin och hälsovetenskap
Mesenchymal Stromal Cells - cytology
Nasal polyps
Nasal Polyps - immunology
Nasal Polyps - pathology
Phenotype
Stem cells
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Summary:Nasal polyposis is a severe, chronic inflammatory condition of the paranasal sinuses and is frequently associated with asthma and aspirin sensitivity. Mesenchymal stem cells exhibit a potent immunosuppressive effect in several inflammatory conditions, and their role in nasal polyposis remains little explored. Hence, we investigated whether bone marrow-derived mesenchymal stem cells could modulate cell phenotype in the nasal polyp milieu. After coculture with mesenchymal stem cells, the frequency of these inflammatory cells was found to decrease. Furthermore, mesenchymal stem cells promoted strong inhibition of CD4+ and CD8+ T cell proliferation, increased the frequency of CD4+CD25+Foxp3 T cells, and changed the global cytokine profile from an inflammatory to an anti-inflammatory response. We believe that mesenchymal stem cells may be a very useful adjunct for investigation of the inflammatory process in nasal polyposis, contributing to better understanding of the inflammatory course of this condition.
ISSN:0962-9351
1466-1861
1466-1861
DOI:10.1155/2014/583409