The Elevated Inflammatory Status of Neutrophils Is Related to In-Hospital Complications in Patients with Acute Coronary Syndrome and Has Important Prognosis Value for Diabetic Patients

Despite neutrophil involvement in inflammation and tissue repair, little is understood about their inflammatory status in acute coronary syndrome (ACS) patients with poor outcomes. Hence, we investigated the potential correlation between neutrophil inflammatory markers and the prognosis of ACS patie...

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Bibliographic Details
Published in:International journal of molecular sciences 2024-05, Vol.25 (10), p.5107
Main Authors: Barbu, Elena, Mihaila, Andreea Cristina, Gan, Ana-Maria, Ciortan, Letitia, Macarie, Razvan Daniel, Tucureanu, Monica Madalina, Filippi, Alexandru, Stoenescu, Andra Ioana, Petrea, Stefanita Victoria, Simionescu, Maya, Balanescu, Serban Mihai, Butoi, Elena
Format: Article
Language:English
Subjects:
acute coronary syndrome
Acute Coronary Syndrome - blood
Acute Coronary Syndrome - complications
Acute coronary syndromes
Aged
Biomarkers - blood
Complications and side effects
Computer software industry
Coronary heart disease
Cytokines
Development and progression
Diabetes
Diabetes Mellitus - blood
Diabetes Mellitus - immunology
Diabetes Mellitus - pathology
Diabetics
Enzymes
Female
Genotype & phenotype
Heart attacks
Humans
Inflammation
Inflammation - blood
Inflammation - pathology
Ischemia
Male
Medical research
Medicine, Experimental
Middle Aged
Mortality
NETs
Neutrophils
Neutrophils - immunology
Neutrophils - metabolism
Patients
Prognosis
prognostic score
Reactive oxygen species
Regression analysis
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Summary:Despite neutrophil involvement in inflammation and tissue repair, little is understood about their inflammatory status in acute coronary syndrome (ACS) patients with poor outcomes. Hence, we investigated the potential correlation between neutrophil inflammatory markers and the prognosis of ACS patients with/without diabetes and explored whether neutrophils demonstrate a unique inflammatory phenotype in patients experiencing an adverse in-hospital outcome. The study enrolled 229 ACS patients with or without diabetes. Poor evolution was defined as either death, left ventricular ejection fraction (LVEF)
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms25105107