Longitudinal Changes of Cytokines and Appetite in Older Hospitalized Patients

• Published in: Nutrients 2021-07, Vol.13 (8), p.2508
• Main Authors: Pourhassan, Maryam, Babel, Nina, Sieske, Lars, Westhoff, Timm Henning, Wirth, Rainer
• Format: Article
• Language: English
• Subjects: Aged patients; Alzheimer's disease; Analysis; appetite; Cognitive ability; Comorbidity; Cytokines; Food; Frailty; Geriatrics; Hospital patients; Hospitalization; Hospitals; IL-1β; Inflammation; Interleukin 10; Interleukin 12; Interleukin 17; Interleukin 18; Interleukin 23; Interleukin 6; Interleukin 8; Malnutrition; Medical research; Medicine, Experimental; Monocyte chemoattractant protein 1; Nutrition; Older people; older persons; Pathophysiology; Patients; Population; Questionnaires; Regression analysis; Serum levels; Tumor necrosis factor; Tumor necrosis factor-TNF; Tumor necrosis factor-α; γ-Interferon
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu13082508

There are few data on the longitudinal association of cytokine and appetite among older hospitalized patients. We aimed to investigate the impact of the changes of inflammatory cytokines on appetite in older hospitalized patients. A total of 191 patients (mean age 81.3 ± 6.6 years, 64% women) participated in this prospective longitudinal observational study. Appetite was evaluated using the Edmonton Symptom Assessment System on admission and after seven days. Serum cytokines such as IL-1β, IL-6, IL-8, IL-10, IL-12p70, IL-17, IL-18, IL-23 and IL-33, IFN-α2, IFN-γ, TNF-α and MCP-1 were measured both times. No significant differences in the mean serum levels of all the cytokines could be detected overtime in relation to appetite changes, except for IL-18. Appetite significantly deteriorated overtime in patients with increasing IL-18 levels and improved in those without significant changes in IL-18 levels. In a stepwise regression analysis, changes of IL-18 levels were the major independent predictor for the changes of patients’ appetite and explained 4% of the variance, whereas other cytokines and variables, such as age, sex, infection and disease, did not show any impact on appetite changes. We conclude that IL-18 seems to exert a significant impact on appetite in acutely ill older hospitalized patients and should, therefore, be considered as a potential target in the diagnosis, prevention and treatment of malnutrition.