Characterization of Nipah virus from outbreaks in Bangladesh, 2008-2010

Nipah virus (NiV) is a highly pathogenic paramyxovirus that causes fatal encephalitis in humans. The initial outbreak of NiV infection occurred in Malaysia and Singapore in 1998-1999; relatively small, sporadic outbreaks among humans have occurred in Bangladesh since 2001. We characterized the compl...

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Bibliographic Details
Published in:Emerging infectious diseases 2012-02, Vol.18 (2), p.248-255
Main Authors: Lo, Michael K, Lowe, Luis, Hummel, Kimberly B, Sazzad, Hossain M S, Gurley, Emily S, Hossain, M Jahangir, Luby, Stephen P, Miller, David M, Comer, James A, Rollin, Pierre E, Bellini, William J, Rota, Paul A
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Amino Acid Substitution
Amino acids
Bangladesh - epidemiology
Chemical properties
Child
Conserved Sequence
Disease Outbreaks
Encephalitis
Female
Genes
Genetic Variation
Genome, Viral
Health aspects
Henipavirus Infections - epidemiology
Henipavirus Infections - virology
Humans
Infection
Molecular Sequence Data
Molecular Typing
Nipah
Nipah virus
Nipah Virus - genetics
Nipah Virus - isolation & purification
outbreak
Phylogeny
Sequence Analysis, DNA
Seroepidemiologic Studies
Viral Proteins - chemistry
Viral Proteins - genetics
viruses
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Description
Summary:Nipah virus (NiV) is a highly pathogenic paramyxovirus that causes fatal encephalitis in humans. The initial outbreak of NiV infection occurred in Malaysia and Singapore in 1998-1999; relatively small, sporadic outbreaks among humans have occurred in Bangladesh since 2001. We characterized the complete genomic sequences of identical NiV isolates from 2 patients in 2008 and partial genomic sequences of throat swab samples from 3 patients in 2010, all from Bangladesh. All sequences from patients in Bangladesh comprised a distinct genetic group. However, the detection of 3 genetically distinct sequences from patients in the districts of Faridpur and Gopalganj indicated multiple co-circulating lineages in a localized region over a short time (January-March 2010). Sequence comparisons between the open reading frames of all available NiV genes led us to propose a standardized protocol for genotyping NiV; this protcol provides a simple and accurate way to classify current and future NiV sequences.
ISSN:1080-6040
1080-6059
DOI:10.3201/eid1802.111492