Brain response in heavy drinkers during cross-commodity alcohol and money discounting with potentially real rewards: A preliminary study

• Published in: Drug and alcohol dependence reports 2023-09, Vol.8, p.100175-100175, Article 100175
• Main Authors: Lungwitz, Elizabeth A., Dzemidzic, Mario, Shen, Yitong I., Plawecki, Martin H., Oberlin, Brandon G.
• Format: Article
• Language: English
• Subjects: Alcoholism; Delayed reward discounting; Ethanol; Full Length Report; Intertemporal choice; Reinforcer; Ventral striatum
• ISSN: 2772-7246; 2772-7246
• DOI: 10.1016/j.dadr.2023.100175

•Heavy drinkers activate ventral frontal cortex when considering immediate alcohol.•Orbitofrontal activation correlated with alcohol-primed wanting for alcohol.•Nucleus accumbens response to alcohol choice correlated with sensation seeking.•Females show more reward activation than males when considering immediate alcohol. Alcohol use disorder (AUD) is associated with exaggerated preference for immediate rewards, a candidate endophenotype for use disorders. Addiction symptomology is often well-described by the preference for immediate intoxication over other delayed prosocial rewards. We measured brain activation in AUD-implicated regions during a cross-commodity delay discounting (CCD) task with choices for immediate alcohol and delayed money. Heavy drinkers (n=24) experienced a brief intravenous alcohol infusion prime, regained sobriety, then chose between ‘One Shot’ and delayed money in an adjusting delay CCD task (sober and intoxicated); also during fMRI (sober). Participants also performed a behavioral sensation seeking task and completed self-report inventories of other risk factors. We assessed brain activation to choices representing immediate intoxication versus delayed money rewards in a priori regions of interest defined within the framework of Addictions NeuroImaging Assessment. Activation to CCD choice versus control trials activated paralimbic and ventral frontal cortical regions, including orbital and medial prefrontal cortex, posterior cingulate/retrosplenial cortex, angular and superior frontal gyri. We detected no differences between immediate or delayed choices. Left medial orbitofrontal cortex activation correlated with alcohol-induced wanting for alcohol; females showed greater activation than males. Behavioral sensation seeking correlated with right nucleus accumbens task engagement. Alcohol decision-making elicited activation in regions governing reward, introspection, and executive decision-making in heavy drinkers, demonstrating the utility of laboratory tasks designed to better model real-world choice. Our findings suggest that the brain processes subserving immediate and delayed choices are mostly overlapping, even with varied commodities. [Display omitted]