Whole-genome sequencing data of Kazakh individuals

• Published in: BMC research notes 2021-02, Vol.14 (1), p.45-45, Article 45
• Main Authors: Kairov, Ulykbek, Molkenov, Askhat, Rakhimova, Saule, Kozhamkulov, Ulan, Sharip, Aigul, Karabayev, Daniyar, Daniyarov, Asset, H Lee, Joseph, D Terwilliger, Joseph, Akilzhanova, Ainur, Zhumadilov, Zhaxybay
• Format: Article
• Language: English
• Subjects: Asians - genetics; Bioinformatics; Bioinformatics analysis; Biotechnology; Data Note; Demographic aspects; Deoxyribonucleic acid; DNA; DNA sequencing; Ethnic groups; Ethnicity - genetics; Genetic aspects; Genome annotation; Genome, Human; Genomes; Genomics; Health aspects; Humans; Kazakh ethnicity; Kazakhstan; Laboratories; Life sciences; Minority & ethnic groups; Mitochondrial DNA; Next-generation sequencing; Nucleotide sequence; Nucleotide sequencing; Population; Population genomics; Population studies; Quality control; Quality management; Whole genome; Whole Genome Sequencing
• ISSN: 1756-0500; 1756-0500
• DOI: 10.1186/s13104-021-05464-4

Kazakhstan is a Central Asian crossroad of European and Asian populations situated along the way of the Great Silk Way. The territory of Kazakhstan has historically been inhabited by nomadic tribes and today is the multi-ethnic country with the dominant Kazakh ethnic group. We sequenced and analyzed the whole-genomes of five ethnic healthy Kazakh individuals with high coverage using next-generation sequencing platform. This whole-genome sequence data of healthy Kazakh individuals can be a valuable reference for biomedical studies investigating disease associations and population-wide genomic studies of ethnically diverse Central Asian region. Blood samples have been collected from five ethnic healthy Kazakh individuals living in Kazakhstan. The genomic DNA was extracted from blood and sequenced. Sequencing was performed on Illumina HiSeq2000 next-generation sequencing platform. We sequenced and analyzed the whole-genomes of ethnic Kazakh individuals with the coverage ranging from 26 to 32X. Ranging from 98.85 to 99.58% base pairs were totally mapped and aligned on the human reference genome GRCh37 hg19. Het/Hom and Ts/Tv ratios for each whole genome ranged from 1.35 to 1.49 and from 2.07 to 2.08, respectively. Sequencing data are available in the National Center for Biotechnology Information SRA database under the accession number PRJNA374772.