Is There a Difference in the Incidence of Depression between Radiation and Surgical Treatments in Patients with Prostate Cancer?

Patients with cancer have a high risk of depression. However, a few studies have assessed differences in the incidence of depression among patients with prostate cancer (PC) based on whether they received radiotherapy (RTx) or surgical treatment. We analyzed data from the National Health Insurance S...

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Bibliographic Details
Published in:The world journal of men's health 2024-01, Vol.42 (1), p.237-244
Main Authors: Tae, Bum Sik, Ahn, Sun Tae, Yoo, Jung Wan, Song, Min Sung, Choi, Hoon, Bae, Jae Hyun, Park, Jae Young
Format: Article
Language:English
Subjects:
depression
Original
prostatic neoplasms
radiotherapy
surgery
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Summary:Patients with cancer have a high risk of depression. However, a few studies have assessed differences in the incidence of depression among patients with prostate cancer (PC) based on whether they received radiotherapy (RTx) or surgical treatment. We analyzed data from the National Health Insurance Sharing Service database regarding the entire Korean adult population with PC (n=210,924) between 2007 and 2017. The adjusted hazard ratios (HRs) of depression associated with treatment were estimated using propensity score-matched Cox proportional hazards models and Kaplan-Meier survival analyses. Our final cohort comprised 9,456 patients with PC; of which, 8,050 men underwent surgery. During a mean follow-up duration of 7.1 years, 503 (5.3%) patients were newly diagnosed with depression. A significant difference in the incidence of depression was noted between the RTx and surgery groups (RTx . surgery: 5.55% 5.28%; p=0.011) in the unmatched cohort. In the matched cohort, older age (≥70 years, HR: 1.596, p
ISSN:2287-4208
2287-4690
DOI:10.5534/wjmh.230119