Real-World Experience in Tricuspid Transcatheter Edge-to-Edge Repair: Transcatheter Tricuspid Valve Repair in Spain Registry

• Published in: Journal of the American Heart Association 2025-01, Vol.14 (2), p.e037070
• Main Authors: Sisinni, Antonio, Barreiro-Perez, Manuel, Freixa, Xavier, Arzamendi, Dabit, Moñivas, Vanessa, Carrasco-Chinchilla, Fernando, Pan, Manuel, Nombela-Franco, Luis, Pascual, Isaac, Benito-González, Tomás, Perez, Ruth, Gómez-Blázquez, Iván, Amat-Santos, Ignacio J, Cruz-González, Ignacio, Sánchez-Recalde, Ángel, Alvarez, Ana Belén Cid, Sanchis, Laura, Caneiro-Queija, Berenice, Li, Chi Hion, Del Trigo, Maria, Martínez-Carmona, Jose David, Mesa, Dolores, Pozo, Eduardo, Avanzas, Pablo, Cepas-Guillén, Pedro, Estévez-Loureiro, Rodrigo
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Cardiac Catheterization - adverse effects; Cardiac Catheterization - instrumentation; Cardiac Catheterization - methods; edge‐to‐edge repair; Female; Heart Valve Prosthesis Implantation - adverse effects; Heart Valve Prosthesis Implantation - instrumentation; Heart Valve Prosthesis Implantation - methods; Humans; Male; Patient Readmission - statistics & numerical data; procedural success; Registries; Retrospective Studies; Risk Factors; Spain - epidemiology; Time Factors; transcatheter treatment; Treatment Outcome; tricuspid regurgitation; Tricuspid Valve - physiopathology; Tricuspid Valve - surgery; Tricuspid Valve Insufficiency - mortality; Tricuspid Valve Insufficiency - physiopathology; Tricuspid Valve Insufficiency - surgery; TRI‐SPA
• ISSN: 2047-9980; 2047-9980
• DOI: 10.1161/JAHA.124.037070

Significant tricuspid regurgitation (TR) is associated with increased morbidity and mortality. The development of transcatheter valve repair therapies has opened a wide range of opportunities for treatment of patients with high surgical risk. Real-world data might improve patient selection and outcome. The authors sought to investigate acute and short-term cardiovascular outcomes of tricuspid transcatheter edge-to-edge repair (T-TEER) with dedicated devices in a real-world setting. This is a retrospective, single-arm, multicenter registry conducted at 15 sites in Spain. The primary end point was a composite of all-cause death, rehospitalization for heart failure, and tricuspid valve re-intervention. Patients included (n=283) were older (76±9 years, 70% female), and showed significant comorbidities. Massive or torrential TR was present in 55% of subjects, with secondary cause being the main mechanism of regurgitation in ≈80% of individuals. Intraprocedural success was achieved in 79% of patients. At 1-year follow-up, significant improvements in TR grade (≥3+, 100% to 25%,