Aminoglycoside Allergic Reactions

Aminoglycosides are antimicrobial agents that are primarily used for infections caused by Gram-negative pathogens. The purpose of this article is to review the allergic reactions reported in the published literature to aminoglycoside antibiotics. A thorough PubMed search was conducted and excluded n...

Full description

Saved in:
Bibliographic Details
Published in:Pharmacy 2019-08, Vol.7 (3), p.124
Main Authors: Childs-Kean, Lindsey M, Shaeer, Kristy M, Varghese Gupta, Sheeba, Cho, Jonathan C
Format: Article
Language:English
Subjects:
Allergies
allergy
amikacin
aminoglycosides
Anaphylaxis
Antibiotics
Cystic fibrosis
Dermatitis
Drug dosages
Drug therapy
Enzymes
gentamicin
hypersensitivity
Infections
Patients
Pharmaceutical sciences
Pharmacy
Review
tobramycin
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c417t-bf7029a6040b05d0e6aa1f18c2fac00c3bebd1482801855d8e6b4f771845fa093
cites cdi_FETCH-LOGICAL-c417t-bf7029a6040b05d0e6aa1f18c2fac00c3bebd1482801855d8e6b4f771845fa093
container_end_page
container_issue 3
container_start_page 124
container_title Pharmacy
container_volume 7
creator Childs-Kean, Lindsey M
Shaeer, Kristy M
Varghese Gupta, Sheeba
Cho, Jonathan C
description Aminoglycosides are antimicrobial agents that are primarily used for infections caused by Gram-negative pathogens. The purpose of this article is to review the allergic reactions reported in the published literature to aminoglycoside antibiotics. A thorough PubMed search was conducted and excluded non-allergic adverse reactions to aminoglycosides. Allergic reactions to aminoglycosides occur infrequently, but can include cutaneous reactions as well as systemic reactions, including anaphylaxis. Of the evaluated aminoglycosides, gentamicin had the most reported allergic reactions, including the most reports of anaphylaxis, followed by tobramycin, and then amikacin. Most reports of allergic reactions occurred in patients who had a prior exposure to some dosage form of an aminoglycoside. Cross-reactivity among aminoglycosides is common and occurs due to the similarities in their chemical structures. Desensitization protocols to tobramycin have been described in the literature.
doi_str_mv 10.3390/pharmacy7030124
format article
fullrecord <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_51659aee6784495696ef70c84411a9d3</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_51659aee6784495696ef70c84411a9d3</doaj_id><sourcerecordid>2283107096</sourcerecordid><originalsourceid>FETCH-LOGICAL-c417t-bf7029a6040b05d0e6aa1f18c2fac00c3bebd1482801855d8e6b4f771845fa093</originalsourceid><addsrcrecordid>eNpdkctrVDEUh4MottSu3UnFjZux5-SdjTAUH4WCILoO5-bmTjPcezMmd4T5741OLW2zyevLl5P8GHuN8EEIB5e7WyoThYMBAcjlM3bKOdcraax5_mB8ws5r3UJrDoVV6iU7ESgNKHCn7O16SnPejIeQa-rjxXocY9mkcPE9UlhSnusr9mKgscbzu_6M_fz86cfV19XNty_XV-ubVZBollU3GOCONEjoQPUQNREOaAMfKAAE0cWuR2m5BWxF9DbqTg7GoJVqIHDijF0fvX2mrd-VNFE5-EzJ_1vIZeOpLCmM0SvUylGM2lgpndJOx3Z7aBNEcr1oro9H127fTbEPcV4KjY-kj3fmdOs3-bdvRqcQmuD9naDkX_tYFz-lGuI40hzzvnrOrUAw4HRD3z1Bt3lf5vZVngvk3EhUslGXRyqUXGuJw30xCP5vmv5Jmu3Em4dvuOf_Zyf-ALW3mhk</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2312274154</pqid></control><display><type>article</type><title>Aminoglycoside Allergic Reactions</title><source>Publicly Available Content Database</source><source>PubMed Central</source><creator>Childs-Kean, Lindsey M ; Shaeer, Kristy M ; Varghese Gupta, Sheeba ; Cho, Jonathan C</creator><creatorcontrib>Childs-Kean, Lindsey M ; Shaeer, Kristy M ; Varghese Gupta, Sheeba ; Cho, Jonathan C</creatorcontrib><description>Aminoglycosides are antimicrobial agents that are primarily used for infections caused by Gram-negative pathogens. The purpose of this article is to review the allergic reactions reported in the published literature to aminoglycoside antibiotics. A thorough PubMed search was conducted and excluded non-allergic adverse reactions to aminoglycosides. Allergic reactions to aminoglycosides occur infrequently, but can include cutaneous reactions as well as systemic reactions, including anaphylaxis. Of the evaluated aminoglycosides, gentamicin had the most reported allergic reactions, including the most reports of anaphylaxis, followed by tobramycin, and then amikacin. Most reports of allergic reactions occurred in patients who had a prior exposure to some dosage form of an aminoglycoside. Cross-reactivity among aminoglycosides is common and occurs due to the similarities in their chemical structures. Desensitization protocols to tobramycin have been described in the literature.</description><identifier>ISSN: 2226-4787</identifier><identifier>EISSN: 2226-4787</identifier><identifier>DOI: 10.3390/pharmacy7030124</identifier><identifier>PMID: 31470509</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Allergies ; allergy ; amikacin ; aminoglycosides ; Anaphylaxis ; Antibiotics ; Cystic fibrosis ; Dermatitis ; Drug dosages ; Drug therapy ; Enzymes ; gentamicin ; hypersensitivity ; Infections ; Patients ; Pharmaceutical sciences ; Pharmacy ; Review ; tobramycin</subject><ispartof>Pharmacy, 2019-08, Vol.7 (3), p.124</ispartof><rights>2019. This work is licensed under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 by the authors. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-bf7029a6040b05d0e6aa1f18c2fac00c3bebd1482801855d8e6b4f771845fa093</citedby><cites>FETCH-LOGICAL-c417t-bf7029a6040b05d0e6aa1f18c2fac00c3bebd1482801855d8e6b4f771845fa093</cites><orcidid>0000-0002-5985-7979</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2312274154/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2312274154?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,313,314,727,780,784,792,885,25751,27920,27922,27923,37010,37011,44588,53789,53791,74896</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31470509$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Childs-Kean, Lindsey M</creatorcontrib><creatorcontrib>Shaeer, Kristy M</creatorcontrib><creatorcontrib>Varghese Gupta, Sheeba</creatorcontrib><creatorcontrib>Cho, Jonathan C</creatorcontrib><title>Aminoglycoside Allergic Reactions</title><title>Pharmacy</title><addtitle>Pharmacy (Basel)</addtitle><description>Aminoglycosides are antimicrobial agents that are primarily used for infections caused by Gram-negative pathogens. The purpose of this article is to review the allergic reactions reported in the published literature to aminoglycoside antibiotics. A thorough PubMed search was conducted and excluded non-allergic adverse reactions to aminoglycosides. Allergic reactions to aminoglycosides occur infrequently, but can include cutaneous reactions as well as systemic reactions, including anaphylaxis. Of the evaluated aminoglycosides, gentamicin had the most reported allergic reactions, including the most reports of anaphylaxis, followed by tobramycin, and then amikacin. Most reports of allergic reactions occurred in patients who had a prior exposure to some dosage form of an aminoglycoside. Cross-reactivity among aminoglycosides is common and occurs due to the similarities in their chemical structures. Desensitization protocols to tobramycin have been described in the literature.</description><subject>Allergies</subject><subject>allergy</subject><subject>amikacin</subject><subject>aminoglycosides</subject><subject>Anaphylaxis</subject><subject>Antibiotics</subject><subject>Cystic fibrosis</subject><subject>Dermatitis</subject><subject>Drug dosages</subject><subject>Drug therapy</subject><subject>Enzymes</subject><subject>gentamicin</subject><subject>hypersensitivity</subject><subject>Infections</subject><subject>Patients</subject><subject>Pharmaceutical sciences</subject><subject>Pharmacy</subject><subject>Review</subject><subject>tobramycin</subject><issn>2226-4787</issn><issn>2226-4787</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNpdkctrVDEUh4MottSu3UnFjZux5-SdjTAUH4WCILoO5-bmTjPcezMmd4T5741OLW2zyevLl5P8GHuN8EEIB5e7WyoThYMBAcjlM3bKOdcraax5_mB8ws5r3UJrDoVV6iU7ESgNKHCn7O16SnPejIeQa-rjxXocY9mkcPE9UlhSnusr9mKgscbzu_6M_fz86cfV19XNty_XV-ubVZBollU3GOCONEjoQPUQNREOaAMfKAAE0cWuR2m5BWxF9DbqTg7GoJVqIHDijF0fvX2mrd-VNFE5-EzJ_1vIZeOpLCmM0SvUylGM2lgpndJOx3Z7aBNEcr1oro9H127fTbEPcV4KjY-kj3fmdOs3-bdvRqcQmuD9naDkX_tYFz-lGuI40hzzvnrOrUAw4HRD3z1Bt3lf5vZVngvk3EhUslGXRyqUXGuJw30xCP5vmv5Jmu3Em4dvuOf_Zyf-ALW3mhk</recordid><startdate>20190829</startdate><enddate>20190829</enddate><creator>Childs-Kean, Lindsey M</creator><creator>Shaeer, Kristy M</creator><creator>Varghese Gupta, Sheeba</creator><creator>Cho, Jonathan C</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7XB</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-5985-7979</orcidid></search><sort><creationdate>20190829</creationdate><title>Aminoglycoside Allergic Reactions</title><author>Childs-Kean, Lindsey M ; Shaeer, Kristy M ; Varghese Gupta, Sheeba ; Cho, Jonathan C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-bf7029a6040b05d0e6aa1f18c2fac00c3bebd1482801855d8e6b4f771845fa093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Allergies</topic><topic>allergy</topic><topic>amikacin</topic><topic>aminoglycosides</topic><topic>Anaphylaxis</topic><topic>Antibiotics</topic><topic>Cystic fibrosis</topic><topic>Dermatitis</topic><topic>Drug dosages</topic><topic>Drug therapy</topic><topic>Enzymes</topic><topic>gentamicin</topic><topic>hypersensitivity</topic><topic>Infections</topic><topic>Patients</topic><topic>Pharmaceutical sciences</topic><topic>Pharmacy</topic><topic>Review</topic><topic>tobramycin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Childs-Kean, Lindsey M</creatorcontrib><creatorcontrib>Shaeer, Kristy M</creatorcontrib><creatorcontrib>Varghese Gupta, Sheeba</creatorcontrib><creatorcontrib>Cho, Jonathan C</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>Proquest Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>Pharmacy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Childs-Kean, Lindsey M</au><au>Shaeer, Kristy M</au><au>Varghese Gupta, Sheeba</au><au>Cho, Jonathan C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aminoglycoside Allergic Reactions</atitle><jtitle>Pharmacy</jtitle><addtitle>Pharmacy (Basel)</addtitle><date>2019-08-29</date><risdate>2019</risdate><volume>7</volume><issue>3</issue><spage>124</spage><pages>124-</pages><issn>2226-4787</issn><eissn>2226-4787</eissn><abstract>Aminoglycosides are antimicrobial agents that are primarily used for infections caused by Gram-negative pathogens. The purpose of this article is to review the allergic reactions reported in the published literature to aminoglycoside antibiotics. A thorough PubMed search was conducted and excluded non-allergic adverse reactions to aminoglycosides. Allergic reactions to aminoglycosides occur infrequently, but can include cutaneous reactions as well as systemic reactions, including anaphylaxis. Of the evaluated aminoglycosides, gentamicin had the most reported allergic reactions, including the most reports of anaphylaxis, followed by tobramycin, and then amikacin. Most reports of allergic reactions occurred in patients who had a prior exposure to some dosage form of an aminoglycoside. Cross-reactivity among aminoglycosides is common and occurs due to the similarities in their chemical structures. Desensitization protocols to tobramycin have been described in the literature.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>31470509</pmid><doi>10.3390/pharmacy7030124</doi><orcidid>https://orcid.org/0000-0002-5985-7979</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2226-4787
ispartof Pharmacy, 2019-08, Vol.7 (3), p.124
issn 2226-4787
2226-4787
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_51659aee6784495696ef70c84411a9d3
source Publicly Available Content Database; PubMed Central
subjects Allergies
allergy
amikacin
aminoglycosides
Anaphylaxis
Antibiotics
Cystic fibrosis
Dermatitis
Drug dosages
Drug therapy
Enzymes
gentamicin
hypersensitivity
Infections
Patients
Pharmaceutical sciences
Pharmacy
Review
tobramycin
title Aminoglycoside Allergic Reactions
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T12%3A55%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Aminoglycoside%20Allergic%20Reactions&rft.jtitle=Pharmacy&rft.au=Childs-Kean,%20Lindsey%20M&rft.date=2019-08-29&rft.volume=7&rft.issue=3&rft.spage=124&rft.pages=124-&rft.issn=2226-4787&rft.eissn=2226-4787&rft_id=info:doi/10.3390/pharmacy7030124&rft_dat=%3Cproquest_doaj_%3E2283107096%3C/proquest_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c417t-bf7029a6040b05d0e6aa1f18c2fac00c3bebd1482801855d8e6b4f771845fa093%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2312274154&rft_id=info:pmid/31470509&rfr_iscdi=true