Effects of the HIV‐1 maturation inhibitor GSK3640254 on QT interval in healthy participants

• Published in: Pharmacology research & perspectives 2023-12, Vol.11 (6), p.e01151-n/a
• Main Authors: Zhang, Ying, Bush, Mark, Yazdani, Parto, Zhan, Joyce, Wen, Bo, Bainbridge, Veronica, Wynne, Brian R., Joshi, Samit, Lataillade, Max
• Format: Article
• Language: English
• Subjects: antiretrovirals; Drug dosages; drug safety; Electrocardiography; Enzymes; Heart rate; Hepatitis; HIV; Human immunodeficiency virus; Medical laboratories; Pharmacokinetics; phase I; Plasma; QT prolongation
• ISSN: 2052-1707; 2052-1707
• DOI: 10.1002/prp2.1151

GSK3640254 (GSK'254) is a novel HIV‐1 maturation inhibitor with pharmacokinetics supporting once‐daily (QD) therapy for HIV‐1 treatment. This thorough QT/corrected QT (QTc) study evaluated the effect of GSK'254 on cardiac repolarization. In this two‐part, randomized study, healthy participants received GSK'254 or placebo QD for 7 days (part 1) to determine safety and pharmacokinetics of a 500‐mg supratherapeutic dose. Four sequential treatment periods composed the main QTc study (part 2): GSK'254 100 mg, GSK'254 500 mg, placebo QD for 7 days, or placebo QD for 6 days with a 400‐mg moxifloxacin dose on Day 7 (all with a moderate‐fat meal). Concentration‐QTc analyses modeled the relationship between GSK'254 plasma concentrations and placebo‐adjusted change from baseline in QT interval corrected with Fridericia's formula (ΔΔQTcF). Of 50 participants enrolled, 48 completed the study (part 1, 8/8; part 2, 40/42). Least‐squares (LS) mean change from baseline in QTcF for GSK'254 100 mg followed the placebo pattern across time points (maximum LS mean ΔΔQTcF, 1.7 ms); the upper bound of the 90% CI remained 10 ms is expected up to GSK'254 concentrations of ~3070 ng mL−1. No clinically relevant effects on cardiac parameters were seen in healthy participants with GSK'254 at the 100‐mg dose. Model‐predicted ΔΔQTc interval at geometric mean GSK'254 concentrations associated with 100‐ and 500‐mg doses.