A comprehensive analysis of association of medical history with airflow limitation: a cross-sectional study

• Published in: International journal of chronic obstructive pulmonary disease 2017-01, Vol.12, p.2363-2371
• Main Authors: Nishida, Yayoi, Takahashi, Yasuo, Tezuka, Kotoe, Yamazaki, Keiko, Yada, Yoichi, Nakayama, Tomohiro, Asai, Satoshi
• Format: Article
• Language: English
• Subjects: Adult; Age; Aged; airflow limitation; Airway obstruction; Airway Obstruction - diagnosis; Airway Obstruction - epidemiology; Airway Obstruction - physiopathology; Analysis; arrhythmia; Asthma; Body mass index; Cardiac arrhythmia; Cardiomyopathy; Cardiovascular disease; Cerebrovascular disease; Chi-Square Distribution; chronic heart disease; Chronic illnesses; Chronic obstructive lung disease; Chronic obstructive pulmonary disease; Comorbidity; Confidence intervals; Cross-Sectional Studies; Databases, Factual; Diabetes; Endocarditis; Female; Heart attacks; Heart Diseases - diagnosis; Heart Diseases - epidemiology; Heart Diseases - physiopathology; Heart failure; heart valve disorder; Hospitals; Humans; Hypertension; Japan - epidemiology; Lung - physiopathology; Lung cancer; Lung Neoplasms - diagnosis; Lung Neoplasms - epidemiology; Lung Neoplasms - physiopathology; Male; Medical history taking; Middle Aged; Mortality; Multivariate Analysis; Odds Ratio; Original Research; Osteoporosis; Patients; Pulmonary Disease, Chronic Obstructive - diagnosis; Pulmonary Disease, Chronic Obstructive - epidemiology; Pulmonary Disease, Chronic Obstructive - physiopathology; Risk Factors; Smoking - adverse effects; Smoking - epidemiology; Software; Spirometry; Tuberculosis; Tuberculosis, Pulmonary - diagnosis; Tuberculosis, Pulmonary - epidemiology; Tuberculosis, Pulmonary - physiopathology; Values
• ISSN: 1178-2005; 1176-9106; 1178-2005
• DOI: 10.2147/COPD.S138103

Multiple comorbidity is common and increases the complexity of the presentation of patients with COPD. This study was a comprehensive analysis of the relationship between a medical history of 22 disease categories and the presence of airflow limitation (AL) without any history of asthma or bronchiectasis, compatible with COPD. A total of 11,898 Japanese patients aged ≥40 years, who underwent spirometry tests, comprising patients with AL (n=2,309) or without AL (n=9,589), were evaluated. Generalized estimating equations were used to assess the relationship between the presence of AL and each disease. The model was adjusted for age, sex, body mass index (BMI) and pack-years of smoking. In multivariate analysis, female sex (odds ratio [OR]: 0.59; 95% confidence interval [CI]: 0.52-0.67), age (OR for 10-year age increase: 1.99; CI: 1.90-2.09), BMI (OR for 1 kg/m increase: 0.96; CI: 0.95-0.98) and smoking history (