Gender differences measured by the MATRICS consensus cognitive battery in chronic schizophrenia patients

Using Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), previous study showed significant gender differences for cognitive deficits in immediate and delayed memory in schizophrenia patients. However, RBANS does not include reasoning and problem solving, and social cognition...

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Bibliographic Details
Published in:Scientific reports 2017-09, Vol.7 (1), p.11821-8, Article 11821
Main Authors: Zhang, Baohua, Han, Mei, Tan, Shuping, De Yang, Fu, Tan, Yunlong, Jiang, Shurong, Zhang, Xiangyang, Huang, Xu-Feng
Format: Article
Language:English
Subjects:
631/477/2811
692/699/476/1799
Cognition & reasoning
Cognitive ability
Females
Gender differences
Humanities and Social Sciences
Information processing
Memory
Mental disorders
multidisciplinary
Problem solving
Schizophrenia
Science
Science (multidisciplinary)
Sex differences
Short term memory
Social interactions
Visual discrimination learning
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Summary:Using Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), previous study showed significant gender differences for cognitive deficits in immediate and delayed memory in schizophrenia patients. However, RBANS does not include reasoning and problem solving, and social cognition. These cognitive functions can significantly affect the outcomes and daily life in patients. This study examined the gender differences of cognition using the measurement and treatment research to improve cognition in schizophrenia (MATRICS) consensus cognitive battery (MCCB), especially focusing on reasoning and problem solving, and social cognition in schizophrenia patients. The results showed that healthy controls exemplified better cognition than patients in both genders in all examined MCCB scores. Male healthy controls had better reasoning and problem solving and working memory than females, but these gender differences were not presented in schizophrenia patients. Also, male schizophrenia patients showed worse cognition than females on social cognition, processing speed, verbal learning and visual learning. Our results support that male schizophrenia patients had more cognitive impairment than females on reasoning and problem solving, social cognition, processing speed, working memory, verbal learning and visual learning.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-12027-w