Long-term efficacy of autologous bone marrow mesenchymal stromal cells for treatment of knee osteoarthritis

Knee osteoarthritis is the most prevalent joint disease and a frequent cause of pain, functional loss and disability. Conventional treatments have demonstrated only modest clinical benefits whereas cell-based therapies have shown encouraging results, but important details, such as dose needed, long-...

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Bibliographic Details
Published in:Journal of translational medicine 2021-12, Vol.19 (1), p.506-506, Article 506
Main Authors: Lamo-Espinosa, José María, Prósper, Felipe, Blanco, Juan F, Sánchez-Guijo, Fermín, Alberca, Mercedes, García, Verónica, González-Vallinas, Margarita, García-Sancho, Javier
Format: Article
Language:English
Subjects:
Arthritis
Autografts
Bone Marrow
Bone Marrow Cells
Care and treatment
Cartilage
Clinical trials
Diagnosis
Epigenetics
Humans
Hyaluronic acid
Injections, Intra-Articular
Intraarticular injection
Joint diseases
Knee
Magnetic resonance imaging
Mesenchymal Stem Cell Transplantation - methods
Mesenchymal Stem Cells
Mesenchyme
Osteoarthritis
Osteoarthritis, Knee - therapy
Pain
Regenerative medicine
Stem cell therapy
Stem cells
Stromal cells
Transplantation
Transplantation, Autologous
Treatment Outcome
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Summary:Knee osteoarthritis is the most prevalent joint disease and a frequent cause of pain, functional loss and disability. Conventional treatments have demonstrated only modest clinical benefits whereas cell-based therapies have shown encouraging results, but important details, such as dose needed, long-term evolution or number of applications required are scarcely known. Here we have reanalyzed results from two recent pilot trials with autologous bone marrow-derived mesenchymal stromal cells using the Huskisson plot to enhance quantification of efficacy and comparability. We find that cell doses of 10, 40 and 100 million autologous cells per knee provided quite similar healing results and that much of the effect attained 1 year after cell application remained after 2 and 4 years. These results are encouraging because they indicate that, apart from safety and simplicity: (i) the beneficial effect is both significant and sizeable, (ii) it can be achieved with a single injection of cells, and (iii) the effect is perdurable for years.Trial registration: EudraCT 2009-017405-11; NCT02123368. Registered 25 April 2014-Prospectively registered, https://clinicaltrials.gov/ct2/show/NCT02123368?term=02123368&draw=2&rank=1.
ISSN:1479-5876
1479-5876
DOI:10.1186/s12967-021-03160-2