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Examining the complex Interplay between gut microbiota abundance and short-chain fatty acid production in amyotrophic lateral sclerosis patients shortly after onset of disease
This study aimed to assess differences in the enteral microbiome of relatively recent-onset amyotrophic lateral sclerosis (ALS) patients (
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| Published in: | Scientific reports 2024-10, Vol.14 (1), p.23497-10, Article 23497 |
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| creator | Fontdevila, Laia Povedano, Mònica Domínguez, Raúl Boada, Jordi Serrano, José CE Pamplona, Reinald Ayala, Victòria Portero-Otín, Manuel |
| description | This study aimed to assess differences in the enteral microbiome of relatively recent-onset amyotrophic lateral sclerosis (ALS) patients ( |
| doi_str_mv | 10.1038/s41598-024-75083-z |
| format | article |
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Fusobacteria
and
Acidobacteria
. ALS subtypes influenced specific species, with increased
Fusobacteria
and
Tenericutes
in spinal ALS compared to bulbar ALS. ALS patients showed increased
Enterobacter
,
Clostridium
,
Veillonella
,
Dialister
,
Turicibacter
,
and Acidaminococcus
species and decreased
Prevotella
,
Lactobacillus
, and
Butyricimonas
. Correlations between species varied between ALS patients and healthy individuals and among ALS subtypes. No significant differences in SCFA concentrations were found, but spinal ALS samples showed a trend towards decreased propionate content. Relationships between SCFAs and phyla colonization differed by disease status. This study suggests distinct enteral microbiome characteristics in ALS patients, though the implications are unclear. Further research is needed to determine if these differences are causative or consequential and to explore their potential as diagnostic or therapeutic targets. The study also underscores the heterogeneity of microbiome constraints in ALS and the need for more research into ALS and SCFA metabolism.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-024-75083-z</identifier><identifier>PMID: 39379597</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>16S sequencing ; 692/617 ; 692/617/375 ; 692/617/375/1917 ; 692/617/375/1917/1285 ; Acid production ; Adult ; Aged ; Alpha-diversity ; Amyotrophic lateral sclerosis ; Amyotrophic Lateral Sclerosis - metabolism ; Amyotrophic Lateral Sclerosis - microbiology ; Case-Control Studies ; Enteral microbiome ; Fatty acids ; Fatty Acids, Volatile - metabolism ; Female ; Fusobacteria ; Gastrointestinal Microbiome ; Heterogeneity ; Humanities and Social Sciences ; Humans ; Intestinal microflora ; Male ; Metabolism ; Microbiomes ; Middle Aged ; multidisciplinary ; Science ; Science (multidisciplinary) ; Short-chain fatty acids ; Therapeutic targets</subject><ispartof>Scientific reports, 2024-10, Vol.14 (1), p.23497-10, Article 23497</ispartof><rights>The Author(s) 2024</rights><rights>2024. The Author(s).</rights><rights>The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2024 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c422t-7dd63f1db18dd90fec6e218b14b4180da996e423cec2867dc37f5b1aec7b7e1a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/3114272804/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/3114272804?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39379597$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fontdevila, Laia</creatorcontrib><creatorcontrib>Povedano, Mònica</creatorcontrib><creatorcontrib>Domínguez, Raúl</creatorcontrib><creatorcontrib>Boada, Jordi</creatorcontrib><creatorcontrib>Serrano, José CE</creatorcontrib><creatorcontrib>Pamplona, Reinald</creatorcontrib><creatorcontrib>Ayala, Victòria</creatorcontrib><creatorcontrib>Portero-Otín, Manuel</creatorcontrib><title>Examining the complex Interplay between gut microbiota abundance and short-chain fatty acid production in amyotrophic lateral sclerosis patients shortly after onset of disease</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>This study aimed to assess differences in the enteral microbiome of relatively recent-onset amyotrophic lateral sclerosis (ALS) patients (< 6–15 months since symptom onset) compared to healthy individuals, focusing on short-chain fatty acids (SCFAs) as potential mediators of host metabolism. We included 28 volunteers (16 ALS, 12 controls) with informed consent. No significant effect of ALS on alpha diversity (measuring the variety and abundance of species within a single sample, and indicating the health and complexity of the microbiome) was observed, but ALS patients had higher abundances of
Fusobacteria
and
Acidobacteria
. ALS subtypes influenced specific species, with increased
Fusobacteria
and
Tenericutes
in spinal ALS compared to bulbar ALS. ALS patients showed increased
Enterobacter
,
Clostridium
,
Veillonella
,
Dialister
,
Turicibacter
,
and Acidaminococcus
species and decreased
Prevotella
,
Lactobacillus
, and
Butyricimonas
. Correlations between species varied between ALS patients and healthy individuals and among ALS subtypes. No significant differences in SCFA concentrations were found, but spinal ALS samples showed a trend towards decreased propionate content. Relationships between SCFAs and phyla colonization differed by disease status. This study suggests distinct enteral microbiome characteristics in ALS patients, though the implications are unclear. Further research is needed to determine if these differences are causative or consequential and to explore their potential as diagnostic or therapeutic targets. The study also underscores the heterogeneity of microbiome constraints in ALS and the need for more research into ALS and SCFA metabolism.</description><subject>16S sequencing</subject><subject>692/617</subject><subject>692/617/375</subject><subject>692/617/375/1917</subject><subject>692/617/375/1917/1285</subject><subject>Acid production</subject><subject>Adult</subject><subject>Aged</subject><subject>Alpha-diversity</subject><subject>Amyotrophic lateral sclerosis</subject><subject>Amyotrophic Lateral Sclerosis - metabolism</subject><subject>Amyotrophic Lateral Sclerosis - microbiology</subject><subject>Case-Control Studies</subject><subject>Enteral microbiome</subject><subject>Fatty acids</subject><subject>Fatty Acids, Volatile - metabolism</subject><subject>Female</subject><subject>Fusobacteria</subject><subject>Gastrointestinal Microbiome</subject><subject>Heterogeneity</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Intestinal microflora</subject><subject>Male</subject><subject>Metabolism</subject><subject>Microbiomes</subject><subject>Middle Aged</subject><subject>multidisciplinary</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Short-chain fatty acids</subject><subject>Therapeutic targets</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNp9ks1u1DAURiMEolXpC7BAltiwCfgvib1CqCowUiU2sLYc-2bGo8QOtgOdvhSviDsppWWBN7Fyj4_vTb6qeknwW4KZeJc4aaSoMeV112DB6psn1SnFvKkpo_Tpg_1JdZ7SHpfVUMmJfF6dMMk62cjutPp1ea0n553forwDZMI0j3CNNj5DnEd9QD3knwAebZeMJmdi6F3IGul-8VZ7A0h7i9IuxFybnXYeDTrnA9LGWTTHYBeTXfCoFPR0CDmGeecMGnXx6xElM0IMySU06-zA57S6xmIYCoKCT5BRGJB1CXSCF9WzQY8Jzu-eZ9W3j5dfLz7XV18-bS4-XNWGU5rrztqWDcT2RFgr8QCmBUpET3jPicBWS9kCp8yAoaLtrGHd0PREg-n6DohmZ9Vm9dqg92qObtLxoIJ26vgixK3SMbvSvmqIFrhtOR-g5dBLaQYAjgUWnLMiLa73q2te-gmsKWOW2R9JH1e826lt-KEI4S0R3a3hzZ0hhu8LpKwmlwyMo_YQlqRYIbmUgnYFff0Pug9L9OVbHSnaUYF5oehKlR-aUoThvhuC1W2-1JovVfKljvlSN-XQq4dz3B_5k6YCsBVIpeS3EP_e_R_tb29b4ag</recordid><startdate>20241008</startdate><enddate>20241008</enddate><creator>Fontdevila, Laia</creator><creator>Povedano, Mònica</creator><creator>Domínguez, Raúl</creator><creator>Boada, Jordi</creator><creator>Serrano, José CE</creator><creator>Pamplona, Reinald</creator><creator>Ayala, Victòria</creator><creator>Portero-Otín, Manuel</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><general>Nature Portfolio</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20241008</creationdate><title>Examining the complex Interplay between gut microbiota abundance and short-chain fatty acid production in amyotrophic lateral sclerosis patients shortly after onset of disease</title><author>Fontdevila, Laia ; Povedano, Mònica ; Domínguez, Raúl ; Boada, Jordi ; Serrano, José CE ; Pamplona, Reinald ; Ayala, Victòria ; Portero-Otín, Manuel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-7dd63f1db18dd90fec6e218b14b4180da996e423cec2867dc37f5b1aec7b7e1a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>16S sequencing</topic><topic>692/617</topic><topic>692/617/375</topic><topic>692/617/375/1917</topic><topic>692/617/375/1917/1285</topic><topic>Acid production</topic><topic>Adult</topic><topic>Aged</topic><topic>Alpha-diversity</topic><topic>Amyotrophic lateral sclerosis</topic><topic>Amyotrophic Lateral Sclerosis - metabolism</topic><topic>Amyotrophic Lateral Sclerosis - microbiology</topic><topic>Case-Control Studies</topic><topic>Enteral microbiome</topic><topic>Fatty acids</topic><topic>Fatty Acids, Volatile - metabolism</topic><topic>Female</topic><topic>Fusobacteria</topic><topic>Gastrointestinal Microbiome</topic><topic>Heterogeneity</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Intestinal microflora</topic><topic>Male</topic><topic>Metabolism</topic><topic>Microbiomes</topic><topic>Middle Aged</topic><topic>multidisciplinary</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Short-chain fatty acids</topic><topic>Therapeutic targets</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fontdevila, Laia</creatorcontrib><creatorcontrib>Povedano, Mònica</creatorcontrib><creatorcontrib>Domínguez, Raúl</creatorcontrib><creatorcontrib>Boada, Jordi</creatorcontrib><creatorcontrib>Serrano, José CE</creatorcontrib><creatorcontrib>Pamplona, Reinald</creatorcontrib><creatorcontrib>Ayala, Victòria</creatorcontrib><creatorcontrib>Portero-Otín, Manuel</creatorcontrib><collection>SpringerOpen</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Science Journals</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fontdevila, Laia</au><au>Povedano, Mònica</au><au>Domínguez, Raúl</au><au>Boada, Jordi</au><au>Serrano, José CE</au><au>Pamplona, Reinald</au><au>Ayala, Victòria</au><au>Portero-Otín, Manuel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Examining the complex Interplay between gut microbiota abundance and short-chain fatty acid production in amyotrophic lateral sclerosis patients shortly after onset of disease</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2024-10-08</date><risdate>2024</risdate><volume>14</volume><issue>1</issue><spage>23497</spage><epage>10</epage><pages>23497-10</pages><artnum>23497</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>This study aimed to assess differences in the enteral microbiome of relatively recent-onset amyotrophic lateral sclerosis (ALS) patients (< 6–15 months since symptom onset) compared to healthy individuals, focusing on short-chain fatty acids (SCFAs) as potential mediators of host metabolism. We included 28 volunteers (16 ALS, 12 controls) with informed consent. No significant effect of ALS on alpha diversity (measuring the variety and abundance of species within a single sample, and indicating the health and complexity of the microbiome) was observed, but ALS patients had higher abundances of
Fusobacteria
and
Acidobacteria
. ALS subtypes influenced specific species, with increased
Fusobacteria
and
Tenericutes
in spinal ALS compared to bulbar ALS. ALS patients showed increased
Enterobacter
,
Clostridium
,
Veillonella
,
Dialister
,
Turicibacter
,
and Acidaminococcus
species and decreased
Prevotella
,
Lactobacillus
, and
Butyricimonas
. Correlations between species varied between ALS patients and healthy individuals and among ALS subtypes. No significant differences in SCFA concentrations were found, but spinal ALS samples showed a trend towards decreased propionate content. Relationships between SCFAs and phyla colonization differed by disease status. This study suggests distinct enteral microbiome characteristics in ALS patients, though the implications are unclear. Further research is needed to determine if these differences are causative or consequential and to explore their potential as diagnostic or therapeutic targets. The study also underscores the heterogeneity of microbiome constraints in ALS and the need for more research into ALS and SCFA metabolism.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>39379597</pmid><doi>10.1038/s41598-024-75083-z</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2045-2322 |
| ispartof | Scientific reports, 2024-10, Vol.14 (1), p.23497-10, Article 23497 |
| issn | 2045-2322 2045-2322 |
| language | eng |
| recordid | cdi_doaj_primary_oai_doaj_org_article_51a806644fe64eb99cfee408084435b1 |
| source | Publicly Available Content Database (Proquest) (PQ_SDU_P3); PubMed Central; Free Full-Text Journals in Chemistry; Springer Nature - nature.com Journals - Fully Open Access |
| subjects | 16S sequencing 692/617 692/617/375 692/617/375/1917 692/617/375/1917/1285 Acid production Adult Aged Alpha-diversity Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - metabolism Amyotrophic Lateral Sclerosis - microbiology Case-Control Studies Enteral microbiome Fatty acids Fatty Acids, Volatile - metabolism Female Fusobacteria Gastrointestinal Microbiome Heterogeneity Humanities and Social Sciences Humans Intestinal microflora Male Metabolism Microbiomes Middle Aged multidisciplinary Science Science (multidisciplinary) Short-chain fatty acids Therapeutic targets |
| title | Examining the complex Interplay between gut microbiota abundance and short-chain fatty acid production in amyotrophic lateral sclerosis patients shortly after onset of disease |
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