Potency of nano-antibacterial formulation from Sargassum binderi against selected human pathogenic bacteria

Seaweeds constitutes an abundant marine reserve that can be harnessed as source of new pharmaceutical agents. Sargassum binderi Sonder ex J. Agardh is a brown seaweed that is predominantly available from December to March in the Red Sea, Jazan, Kingdom of Saudi Arabia (KSA). In this study, three ext...

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Bibliographic Details
Published in:Brazilian Journal of Pharmaceutical Sciences 2018-01, Vol.54 (4)
Main Authors: Moni, Sivakumar Sivagurunathan, Alam, Mohammad Firoz, Safhi, M M., Jabeen, Aamena, Sanobar, Syeda, Siddiqui, Rahimullah, Moochikkal, Remesh
Format: Article
Language:English
Subjects:
Algae
Antibacterial formulations
Antibiotics
Bacteria
Bacterial infections
Carbohydrates
Drug resistance
E coli
Fatty acid vesicles
Natural products
Permeability
PHARMACOLOGY & PHARMACY
Phytochemicals
Red sea
Sargassum species
Scanning electron microscopy
Solvents
Spectrum analysis
Variance analysis
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Summary:Seaweeds constitutes an abundant marine reserve that can be harnessed as source of new pharmaceutical agents. Sargassum binderi Sonder ex J. Agardh is a brown seaweed that is predominantly available from December to March in the Red Sea, Jazan, Kingdom of Saudi Arabia (KSA). In this study, three extracts were isolated using three different techniques, and were subjected to antibacterial assay. The petroleum ether extract of Sargassum binderi was more effective against selected human pathogenic bacteria than the other extracts. Therefore, further studies were focused on developing oleic acid vesicles entrapped with the petroleum ether extract of Sargassum binderi, with the aim of enhancing its penetration property. Oleic acid vesicles were prepared by entrapping petroleum ether extract of Sargassum binderi using film hydration technique. The formulated vesicles were in nanoscale, and so were termed phyto-nanovesicles (PNVs). The spectrum of antibacterial activity of PNVs showed that it is a promising formulation against S. aureus, S. pyogenes, B. subtilis, E. coli, K. pneumoniae and P. aeruginosa. The microbial sensitivities to the PNVs was in the order E.coli > B. subtilis > S. aureus > S. pyogenes > K. pneumoniae > P. aeruginosa. Thus, the PNV formulation possesses promising and effective antimicrobial potential against human pathogenic bacteria.
ISSN:2175-9790
1984-8250
2175-9790
DOI:10.1590/s2175-97902018000417811